2-Amino-3- (4-hydroxyphenyl) propanoic acid Cas: 556-03-6 99% Crystalline
Lambar Catalog | XD90297 |
Sunan samfur | 2-Amino-3- (4-hydroxyphenyl) propanoic acid |
CAS | 556-03-6 |
Tsarin kwayoyin halitta | Saukewa: C9H11NO3 |
Nauyin Kwayoyin Halitta | 181.18854 |
Bayanin Ajiya | Yanayin dakin |
Harmonized Tariff Code | Farashin 29225000 |
Ƙayyadaddun samfur
Assay | 99% |
Bayyanar | Crystalline |
An nuna furotin na cerebral dopamine neurotrophic factor (CDNF) don kare hanyar nigrostriatal dopaminergic lokacin da aka ba da shi azaman infusions intrastriatal a cikin bera da nau'ikan linzamin kwamfuta na cutar Parkinson (PD).A cikin wannan binciken, mun kimanta tasirin neuroprotective na CDNF wanda aka kawo tare da recombinant adeno-associated viral (AAV) serotype 2 vector a cikin rat 6-hydroxydopamine (6-OHDA) samfurin PD.AAV2 vectors ɗin da ke ɓoye CDNF, glial cell line-derived neurotrophic factor (GDNF), ko furotin mai kyalli ko kore an allura a cikin bera striatum.Binciken furuci na furotin ya nuna cewa vector ɗin mu na AAV2 ya isar da ƙayyadaddun kwayoyin halittar neurotrophic a cikin kwakwalwa kuma ya haifar da bayanin sunadaran na dindindin.Makonni biyu bayan allurar vector na AAV2, 6-OHDA an allurar a cikin bera striatum, yana haifar da haɓakar ci gaba na tsarin dopaminergic na nigrostriatal.Jiyya tare da AAV2-CDNF ya haifar da raguwa mai mahimmanci a cikin jujjuyawar ipsilateral na amphetamine yayin da yake ba da kariya kawai na tyrosine hydroxylase (TH) -immunoreactive Kwayoyin a cikin bera substantia nigra pars compacta da TH-reactive fibers a cikin striatum.Sakamakon wannan binciken ya ba da ƙarin shaida cewa CDNF za a iya la'akari da yiwuwar maganin cutar Parkinson