Kayayyaki

Toxin Ricin (RT) ita ce ta biyu mafi muni da aka sani;CDC ce ta ayyana shi a matsayin wakili mai zaɓi.Ana yin RT ta hanyar shukar wake;ana samar da kimanin tan 50,000 na RT a duk shekara a matsayin samfurin man kasko.RT yana da sassan biyu, sarkar ribotoxic A (RTA) da sarkar galactose-binding B (RTB).RT yana ɗaure ga duk ƙwayoyin dabbobi masu shayarwa kuma da zarar an shiga ciki, RTA guda ɗaya yana kashe duk ribosomes a cikin tantanin halitta.Ana gudanar da shi azaman aerosol, RT yana haifar da lalacewar huhu da sauri da fibrosis wanda ke biye da mutuwa.Babu wasu alluran rigakafin da Hukumar Abinci da Magunguna ta amince da ita kuma magunguna suna da tasiri kawai a cikin ƴan sa'o'i na farko bayan fallasa.Mun ƙirƙiri maganin rigakafi na RTA wanda ke da maye gurbi biyu V76M/Y80A (RiVax).An bayyana furotin a cikin Escherichia coli kuma ba mai guba bane kuma yana da rigakafi a cikin beraye, zomaye, da mutane.Lokacin da aka ƙalubalanci berayen da aka yi wa alurar riga kafi tare da allura, aerosolized, ko na baki (gavaged) RT, ana kiyaye su gaba ɗaya.Yanzu mun ƙaddamar da wani tsari na RiVax wanda ke ɗauke da thermostable, aluminum-adjuvant kuma mun gwada shi a cikin macaques rhesus.Bayan allura guda uku, dabbobin sun samar da ƙwayoyin rigakafi waɗanda ke kare su gaba ɗaya daga wani nau'in kisa na aerosolized RT.Waɗannan ƙwayoyin rigakafi sun kawar da RT kuma sun yi gasa zuwa digiri daban-daban tare da panel na neutralizing da rashin daidaituwar ƙwayoyin rigakafi na linzamin kwamfuta na monoclonal da aka sani don gane takamaiman ƙayyadaddun abubuwa akan RTA na asali.Sakamakon bayanin gasar gasa na iya wakiltar sa hannun kariya na rigakafi.Mahimmanci, an lura da sa hannu iri ɗaya ta amfani da sera daga mutanen da aka yi wa RiVax rigakafi.