Kayayyaki

(+) (3R, 5S), tert-Butyl 7-[4- (4-fluorophenyl) -6-isopropyl-2- (N-methyl-N-methylsulphonylamino) -pyrimidin-5-yl] -3,5 -dihydroxy-6 (E) -heptenate, wanda kuma aka sani da R1.5 ko tert-butyl-rosuvastatin, wani sinadari ne mai yuwuwar aikace-aikace a cikin masana'antar harhada magunguna. kwayoyi da ake kira statins.Yana aiki ta hanyar hana wani enzyme mai suna HMG-CoA reductase, wanda ke da hannu wajen samar da cholesterol a cikin jiki.R1.5 wani nau'i ne na rosuvastatin wanda ya ƙunshi ƙungiyar tert-butyl da aka haɗe zuwa kwayoyin halitta, yana ba da ƙarin kaddarorin da fa'idodi.Kamar rosuvastatin, ana iya amfani da R1.5 don rage matakan LDL cholesterol, wanda kuma aka sani da "mummunan" cholesterol, da triglycerides a cikin jini.Wannan fili na iya nuna ingantattun kaddarorin harhada magunguna, kamar haɓakar yanayin rayuwa ko ingantaccen kwanciyar hankali, idan aka kwatanta da magungunan iyaye.Bugu da ƙari kuma, ƙungiyar tert-butyl na iya ba da gudummawa ga madaidaicin fili da haɓakar ƙira, yana sa ya dace da tsarin isar da magunguna daban-daban.Wani yuwuwar amfani da R1.5 yana cikin haɓakar magunguna ko tsarin isar da magunguna da aka yi niyya.Rukunin tert-butyl na iya aiki azaman ƙungiyar kariya, yana ba da damar sarrafa sakin rosuvastatin a cikin takamaiman kyallen takarda ko gabobin, kamar hanta.Wannan dabarar za ta iya haɓaka tasirin maganin da kuma rage yiwuwar sakamako masu illa ta hanyar ƙara yawan maida hankali a wurin da aka yi niyya yayin da rage fallasa ga kyallen da ba a kai ba. Bugu da ƙari, R1.5 na iya zama kayan aiki mai mahimmanci ga masanan magunguna a cikin ganowa da haɓakar ƙwayoyi.Tsarin hadadden mahallin yana ba da dandamali don ƙarin gyare-gyare da gyare-gyare.Masu bincike za su iya amfani da R1.5 azaman jagorar jagora don bincika alaƙa-ayyukan ayyuka da haɓaka sabbin analogs tare da ingantaccen ƙarfi, zaɓi, ko ingantattun bayanan warkewa.Irin waɗannan karatun na iya ba da gudummawa ga haɓakar novel kuma mafi inganci statins ko wasu wakilai masu rage cholesterol. -2- (N-methyl-N-methylsulphonylamino) -pyrimidin-5-yl] -3,5-dihydroxy-6 (E) -heptenate (R1.5 ko tert-butyl-rosuvastatin) yana ɗaukar alƙawarin azaman fili na magunguna don maganin hyperlipidemia da cututtukan zuciya.Tsarinsa na musamman, haɗe tare da ƙungiyar tert-butyl, na iya samar da fa'idodi kamar ingantattun magunguna, isar da magunguna da aka yi niyya, da damar ci gaba da haɓaka magunguna.Ana buƙatar ƙarin bincike da haɓaka don cikakken bincika yuwuwar R1.5 a fagen magunguna.