Kayayyaki

4-[6- (6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido [2,3-d] pyrimidin-2-ylamino) -pyridin-3-yl] - piperazine-1-carboxylic acid tert-butyl ester wani fili ne tare da yuwuwar amfani da shi a cikin binciken harhada magunguna da haɓaka magunguna.Tsarinsa mai rikitarwa da ƙungiyoyi masu aiki suna ba da dama daban-daban don bincike da bincike game da aikace-aikacen warkewa. Ɗayan yuwuwar aikace-aikacen wannan fili shine a fagen ilimin oncology.Kasancewar ƙungiyar bromo da pyrido [2,3-d] pyrimidin moiety yana nuna cewa yana iya samun aikin maganin ciwon daji.An san ƙungiyar bromo don yuwuwar ta don hana haɓakar salula da haifar da apoptosis a cikin ƙwayoyin kansa.Bugu da ƙari, pyrido [2,3-d] pyrimidin scaffold yana da alaƙa da anti-proliferative da anti-tumo effects.Don haka, ana iya ƙara nazarin wannan fili don yuwuwar sa a matsayin sabon wakili na rigakafin ciwon daji.Bugu da ƙari, ƙungiyoyin cyclopentyl da methyl da ke cikin tsarin suna sanya mahaɗin lipophilic, wanda zai iya ba da gudummawa ga ikonsa na ketare shingen nazarin halittu, kamar jini. - shingen kwakwalwa.Wannan dukiya yana buɗe yiwuwar yin amfani da shi a cikin ci gaba da magungunan da ke fama da cututtuka na tsarin juyayi na tsakiya, irin su cututtukan cututtuka.Za'a iya gyare-gyaren fili don haɓaka zaɓinsa da ƙarfinsa a kan takamaiman maƙasudin da ke cikin waɗannan cututtuka. Bugu da ƙari, kasancewar piperazine-1-carboxylic acid tert-butyl ester moiety yana nuna cewa fili na iya samun amfani a matsayin prodrug.Prodrugs mahadi ne marasa aiki waɗanda za a iya jujjuya su zuwa nau'ikan aiki a cikin jiki.Ƙungiyar tert-butyl ester na iya zama ƙungiya mai kariya, tare da hana kunna maganin da wuri kafin ya isa wurin da ake so.Da zarar ya kai ga nama ko sel, ƙungiyar ester za a iya rushewa ta hanyar enzymatically, ta sake sakin kwayoyin miyagun ƙwayoyi masu aiki.Bugu da ƙari kuma, pyridine da pyrimidine na fili yana nuna yiwuwarsa a matsayin pharmacophore don tsara masu hana masu hanawa don takamaiman enzymes ko masu karɓa.Waɗannan suna iya kewayawa daga kinase zuwa masu karɓar furotin G, dangane da gyare-gyaren da aka yi zuwa ainihin tsarin.Wannan fili zai iya zama mafari don nazarin tsarin-aiki-aiki da kuma jagoranci ingantawa don haɓaka masu hanawa masu ƙarfi da zaɓaɓɓu don takamaiman maƙasudin warkewa.A taƙaice, 4-[6- (6-bromo-8-cyclopentyl-5-methyl-7) -oxo-7,8-dihydro-pyrido [2,3-d] pyrimidin-2-ylamino -pyridin-3-yl] -piperazine-1-carboxylic acid tert-butyl ester yana nuna yiwuwar a wurare daban-daban na bincike na magunguna.Tsarinsa na musamman da ƙungiyoyin aiki za a iya ƙara bincikowa don aikin rigakafin ciwon daji, haɓakar ƙwayar cuta ta tsakiya, dabarun samar da magunguna, da zaɓin enzyme ko hana mai karɓa.Ci gaba da bincike da haɓaka wannan fili na iya haifar da gano sabbin zaɓuɓɓukan warkewa tare da ingantacciyar inganci da ƙayyadaddun manufa.