An gudanar da berayen kashi ɗaya na asalin shuka phenolic antioxidant Quercetin (QC) a cikin kyauta, liposome encapsulated da galactosylated liposome encapsulated siffofin 2 h kafin hepatotoxic kashi na carbontetrachloride (CCl4, 40% v / v a cikin man zaitun, 1 ml/kg b). .wt).Daga cikin waɗancan nau'ikan nau'ikan nau'ikan QC guda uku da aka gwada, kawai galactosylated liposomal QC sun ba da babbar kariya daga CCl4 da ke haifar da lalacewar hanta.Bayan sa'o'i 24 na allura (SC) an gano ƙwayoyin hanta na berayen masu saurin kamuwa da cutar CCl4 da ke haifar da lalatawar iskar oxygen kuma ana lura da shi ta yawan adadin diene mai haɗuwa a cikin membrane na hanta.An rage ninki biyu a cikin diene mai haɗaɗɗiyar ta hanyar shigar da CCl4 zuwa matakin al'ada ta hanyar riga-kafi na QC galactosylated liposomal.Carbontetrachloride ya haifar da lalacewar membrane a cikin ƙwayoyin hanta kuma an yi masa hukunci ta hanyar gwajin cututtukan jini da na hanta na histopathological.Lalacewar ƙwayar cuta ta hanyar shigar da CCl4 an ƙara kimantawa ta hanyar raguwar matakin plasma membrane (PM) daure enzyme Na +/K+ ATPase aiki kuma an ƙara shi ta hanyar riga-kafi na galactosylated liposomal QC.Carbontetrachloride ya haifar da raguwa mai mahimmanci duka a cikin enzymatic da kwayoyin endogenous antioxidant matakan a cikin kwayoyin hanta. An hana damuwa a cikin tsarin antioxidant a cikin kwayoyin hanta gaba daya ta hanyar kashi ɗaya na galactosylated lipsosomal QC kafin maganin CCl4.An kiyasta ɗaukar hanta na QC bayan 2 h na allurar flavonoid (8.9 micromol/kg nauyin jiki) (nauyin kyauta ko lipsomal) kuma 85% na allurar QC an samo shi a cikin hanta a cikin yanayin galactosylated liposomal QC.Ganin cewa kashi 25% na allurar da aka yi wa allurar an gano a hanta lokacin da aka yi allurar QC iri ɗaya.Carbontetrachloride kuma ya haifar da canji a cikin ruwa na membrane kuma an ƙididdige shi ta hanyar raguwar ƙananan dankowar membrane.Maganin farko na QC kyauta ya haifar da rashin kariya daga CCl4 da ke haifar da karuwa a cikin ruwan hanta na hanta, yayin da galactosylated liposomal QC ya ba da kariya mai mahimmanci akan karuwa.Sakamakon wannan binciken ya nuna cewa QC a cikin liposome galactosylated zai iya ba da kariya mai mahimmanci daga raunin hanta na CCl4.
