Kayayyaki

6-Acetyl-8-cyclopentyl-5-methyl-2-[5- (1-piperazinyl) -2-pyridinyl] amino] pyrido [2,3-d] pyrimidin-7 (8H) -daya hydrochloride wani fili ne. tare da yuwuwar aikace-aikace a cikin binciken harhada magunguna da haɓakar magunguna.Tsarinsa na musamman na kwayoyin halitta yana ba da damar yin bincike game da amfaninsa na warkewa.Wannan fili yana cikin dangin pyrido [2,3-d] pyrimidinone, wanda aka yi nazari sosai don ayyukansa na harhada magunguna.Kasancewar ƙungiyar acetyl yana ba da shawarar yuwuwar hulɗa tare da enzymes da ke cikin hanyoyin salula.Yana iya samun tasirin hanawa akan enzymes kamar kinases ko proteases, yana mai da shi dan takara mai ban sha'awa don ci gaba da masu hanawa na musamman na enzyme.Cyclopentyl da methyl kungiyoyin a cikin tsarin suna ba da gudummawa ga yanayin lipophilic na fili.Wannan kadarorin yana ba shi damar ƙetare shingen nazarin halittu cikin sauƙi, yana haɓaka yuwuwar sa a matsayin ɗan takarar miyagun ƙwayoyi.Yana iya haɓaka haɓakar haɓakawa da haɓakar rayuwa, yana sa ya dace da gudanarwar baka da rarraba tsarin.Rukunin 1-piperazinyl da 2-pyridinyl da ke cikin mahallin suna ba da damar yin amfani da shi a cikin ƙirar ƙwayoyi.Abubuwan da aka samo asali na Piperazine an san su sosai a cikin sinadarai na magani don ayyukansu na halitta.Ƙungiyar piperazine na iya ba da gudummawa ga ɗaurin mai karɓa da daidaita kaddarorin pharmacokinetic.Bugu da ƙari, ƙungiyar pyridine sau da yawa yana shiga cikin hulɗar ligand-receptor, kamar yadda tsarin zobe na pyridine zai iya samar da haɗin gwiwar hydrogen tare da takamaiman wuraren masu karɓa.Wadannan kaddarorin suna yin wannan fili mai yuwuwar ligand don masu karɓa daban-daban, ciki har da masu karɓa na G sunadaran da aka haɗa. .Yana iya nuna tasirin cytotoxic akan kwayoyin cutar kansa ta hanyar hana takamaiman hanyoyin sigina da ke da alaƙa da haɓakar tantanin halitta.Ƙarin nazarin da ke tattare da in vitro da in vivo model na iya kimanta yiwuwarsa a matsayin wakili na anti-tumor. Bugu da ƙari, pyrido [2,3-d] pyrimidinone core za a iya gyare-gyare don ƙaddamar da cututtuka ko yanayi na musamman.Ta hanyar gabatar da ƙungiyoyi masu aiki masu dacewa ko masu maye gurbinsa, za'a iya haɓaka zaɓin sa da ƙarfinsa, yana ba da damar haɓaka takamaiman magungunan warkewa. piperazinyl) -2-pyridinyl] amino] pyrido [2,3-d] pyrimidin-7 (8H) -daya hydrochloride yana riƙe da yuwuwar a wurare da yawa na binciken magunguna.Siffofin tsarin sa suna ba da damar yin bincike kan hanawar enzyme, ɗaure mai karɓa, da aikin rigakafin ciwon daji.Ƙarin bincike da haɓaka ainihin tsarin sa na iya samar da sabbin ƴan takarar magunguna tare da ingantacciyar inganci da ƙayyadaddun maƙasudin jiyya daban-daban.