Kayayyaki

Ƙungiyoyi uku na manya cynomolgus birai (Macaca fascicularis) an fallasa su zuwa ko dai 200 micrograms/m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], 200 micrograms (NH4) 2PtCl6 a lokaci guda tare da 1 ppm ozone (O3), ko zuwa 3 kawai.An fallasa dabbobin ta hanyar inhalation na sa'o'i 6 kowace rana, kwanaki 5 a kowane mako don 12 wk.Ƙirar gwaji ta haɗa da preexposure na methacholine da Na2PtCl6 ƙalubalen ƙalubalen bronchoprovocation, gwajin fata na Na2PtCl6, da sera don nazarin ƙwayoyin rigakafi.Makonni biyu bayan bayyanar 12-wk, an sake kimanta waɗannan fihirisar.Ayyukan huhu na asali ba su da tasiri sosai ta hanyar tsarin bayyanarwa;duk da haka, haɗin kai ga O3 da (NH4) 2PtCl6 ya rage yawan ƙwayar platinum (Pt) gishiri da methacholine wajibi ne don ƙara yawan juriya na huhu (RL) 200% (EC200 RL).Ozone ko bayyanar Pt kadai ba shi da wani tasiri mai mahimmanci akan waɗannan sigogi.Ƙimar Platinum da methacholine EC200 RL sun kasance suna da alaƙa sosai ga ƙungiyoyin da aka fallasa Pt bayan fallasa.Waɗannan bayanan sun nuna cewa haɗewar O3 da Pt sun ƙaru musamman musamman (Pt) da rashin takamaiman (methacholine) hyperreactivity na buroshi sau da yawa fiye da bayyanar da ko dai O3 ko Pt gishiri kaɗai.Haɗin O3 tare da bayyanar Pt shima yana haɓaka haɓakar ingantaccen gwajin fata na Pt idan aka kwatanta da sauran ƙungiyoyin fallasa.Kama da kwarewar ɗan adam, gwajin radioallergosorbent (RAST) don takamaiman ƙwayoyin rigakafi na Pt ba su da mahimmanci kamar gwajin fata kai tsaye wajen gano masu rashin lafiyan.