Kayayyaki

An yi amfani da gel ɗin Chitosan-dextran azaman wakili na antihemostatic da wakili na antiadhesive bayan tiyatar sinus na endoscopic.Saboda Staphylococcus aureus biofilms sun shiga cikin recalcitrant na kullum rhinosinusitis, wannan binciken da nufin kara bincikar (i) anti-mai kumburi, (ii) kwayoyin biofilm hanawa, (iii) antiproliferative effects, da (iv) raunuka-warkar Properties na chitosan da kuma chitosan-dextran gel.Fibroblasts an ware su daga ƙwayar hanci na mutum kuma an yi amfani da su don ƙayyade tasirin chitosan da chitosan-dextran gel akan (i) yaduwar kwayar halitta, (ii) warkar da rauni, (iii) kumburi a cikin al'adun fibroblast da aka kalubalanci superantigens S. aureus enterotoxin B (SEB) da toxic shock syndrome toxin (TSST), da (iv) akan S. aureus biofilms.Chitosan ya kasance mai tasiri sosai wajen rage IL-8 magana bayan TSST da SEB kalubale.Chitosan kuma yana da tasiri wajen rage IL-8 magana na fibroblasts marasa ƙalubale yana nuna tasirin sa na hana kumburi akan fibroblasts a cikin jihar adseased.Chitosan-dextran gel ya nuna kaddarorin antibiofilm mai ƙarfi a 50% (v / v) maida hankali a cikin vitro.Dextran, a kan kansa, ya nuna alamun antibiofilm a 1.25% (w / v) maida hankali.Chitosan, a kan kansa, ya rage yawan ƙwayar fibroblasts zuwa 82% na haɓakawa na sarrafawa da kuma chitosan-dextran gel ya rage yaduwar fibroblasts zuwa 0.04% na haɓakawa.Dangantakar da babu kulawar kulawa, chitosan-dextran gel ya jinkirta jinkirin raunin raunin da ya faru a cikin sa'o'i 48 na farko na gwaji. lokaci.Chitosan ya rage matakan IL-8, yana nuna kayan anti-mai kumburi.Chitosan-dextran gel da dextran jiyya sun nuna alamun antibiofilm a cikin samfurin mu.