Kayayyaki

Bromelain (BR) shine protease na cysteine ​​tare da tasirin hanawa akan ɓoyewar hanji da kumburi.Duk da haka, ba a gano tasirinsa akan motsin hanji ba.Don haka, mun bincika tasirin wannan fili da aka samu na shuka akan ƙarancin hanji da wucewa a cikin mice. An ƙididdige kwangilar a cikin vitro ta hanyar motsa jikin da aka keɓe na linzamin kwamfuta, a cikin wanka na gabobin jiki, tare da acetylcholine, barium chloride, ko haɓakar filin lantarki.Motsin motsi a cikin vivo an auna ta hanyar kimanta rarraba alamar mai walƙiya ta baki tare da ƙaramin hanji.An kuma yi la'akari da hanyar wucewa a cikin jihohin pathophysiologic wanda aka haifar da pro-mai kumburi fili croton man ko ta hanyar streptozotocin wakili na diabetogenic.Bromelain ya hana ƙaddamar da ƙwayoyin spasmogenic daban-daban a cikin linzamin kwamfuta tare da irin wannan iko.An rage ko rage tasirin maganin antispasmodic ta hanyar mai hana enzyme proteolytic, gabexate (15 × 10 (-6) mol L (-1) , protease-activated r eceptor-2 (PAR-2) antagonist, N (1) -3 -methylbutyryl-N (4) -6-aminohexanoyl-piperazine (10 (-4) mol L (-1) phospholipase C (PLC) inhibitor, neomycin (3 × 10 (-3) mol L (-1)). , da phosphodiesterase 4 (PDE4) mai hanawa, rolipram (10 (-6) mol L (-1)).A cikin vivo, BR ya fi son hana motsi a cikin jihohin pathophysiologic a cikin hanyar PAR-2-antagonist-m. Bayananmu sun nuna cewa BR yana hana motsin hanji - yafi dacewa a cikin yanayin pathophysiologic - tare da wata hanyar da za ta iya haɗawa da membrane PAR-2 ​​da PLC da PDE4 a matsayin intracellular. sigina.Bromelain zai iya zama fili mai gubar don haɓaka sababbin magunguna, yana iya daidaita motsin hanji a cikin kumburi da ciwon sukari.