Kayayyaki

Cystic fibrosis cuta ce ta kwayoyin halittar da ke tattare da kumburi mara kyau a cikin huhu da kamuwa da kamuwa da cuta mai dorewa.Matsanancin huhu shine lokacin da alamun kamuwa da cuta suka fi tsanani.Magungunan rigakafi wani yanki ne mai mahimmanci na jiyya don ɓarna kuma ana iya amfani da maganin rigakafi da aka shaka shi kaɗai ko a haɗe tare da maganin rigakafi na baka don ƙara ƙaranci ko tare da maganin rigakafi na cikin jijiya don ƙarin cututtuka masu tsanani.Magungunan rigakafi da aka shaka ba sa haifar da illa iri ɗaya kamar maganin rigakafi na ciki kuma yana iya tabbatar da madadin a cikin mutanen da ba su da damar shiga jijiyarsu.Don sanin ko maganin cututtukan huhu tare da maganin rigakafi na inhaled a cikin mutanen da ke da cystic fibrosis yana inganta rayuwarsu, yana rage lokacin hutu. makaranta ko aiki da kuma inganta rayuwarsu na dogon lokaci.Mun bincika ClinicalTrials.gov da Australiya da New Zealand Clinical Trials Registry don gwaji masu dacewa.Kwanan binciken ƙarshe: 15 Maris 2012 Mun kuma bincika Cochrane Cystic Fibrosis G roup's Cystic Fibrosis Trials Register.Kwanan bincike na ƙarshe: 01 Yuni 2012. Gwajin da aka ba da izini a cikin mutanen da ke fama da cystic fibrosis tare da ciwon huhu wanda aka kwatanta da maganin rigakafi tare da maganin rigakafi da aka kwatanta da placebo, daidaitaccen magani ko wani kwayoyin da aka shayar da shi don tsakanin makonni daya da hudu. Biyu bita marubuta da kansu. gwaje-gwajen da aka zaɓa waɗanda aka zaɓa, sun kimanta haɗarin rashin son zuciya a cikin kowane gwaji da fitar da bayanai.An tuntuɓi marubutan gwaje-gwajen da aka haɗa don ƙarin bayani. An haɗa gwaje-gwaje shida tare da mahalarta 208 a cikin bita.Gwaje-gwaje sun kasance iri-iri a cikin ƙira da shiga tsakani (duk da haka, duk sun haɗa da gwaje-gwaje idan aka kwatanta da inhaled da magungunan ƙwayoyin cuta na ciki).Hadarin son zuciya ya kasance mai wuyar tantancewa a yawancin gwaji.Ba a cika ba da rahoton sakamako ba kuma an sami taƙaitaccen bayanai kawai don bincike.Gwaji guda huɗu sun ba da rahoton wasu sakamako akan ƙarar karewa ta tilas a cikin daƙiƙa ɗaya kuma ba a sami wani bambance-bambance ba tsakanin maganin rigakafin da aka shaka da sa hannun ɗan kwatancen.A cikin biyu daga cikin waɗannan gwaje-gwajen ta amfani da 300 MG na tobramycin inhaled, canjin ƙarar tilastawa a cikin daƙiƙa ɗaya yayi kama da tobramycin na ciki;kuma a cikin wani gwaji lokaci har zuwa na gaba exerbation bai bambanta ba.Ba a ba da rahoton wani tasiri mai mahimmanci ba. Akwai ƙananan shaida mai mahimmanci don yin la'akari da tasirin maganin rigakafi da aka shayar da shi don maganin cututtuka na huhu a cikin mutanen da ke da cystic fibrosis.Gwaje-gwajen da aka haɗa ba su da isasshen ƙarfi don cimma burinsu.Don haka, ba za mu iya nuna ko ɗaya magani ya fi ɗaya ko a'a ba.Ana buƙatar ƙarin bincike don gano ko za a iya amfani da tobramycin inhaled a matsayin madadin tobramycin na cikin jijiya don wasu cututtukan huhu.