Kayayyaki

Tasiri mara kyau yana da mahimmanci don ba da rauni ga jarabar opiate kamar yadda babban haɓakar cin zarafi na opiate ya nuna tare da babban rashin damuwa (MDD).Samfuran rodent suna haifar da amygdala prodynorphin (Pdyn) a matsayin matsakanci na mummunan tasiri;duk da haka, shaidar shigar PDYN a cikin mummunan tasirin ɗan adam yana da iyaka.Anan, mun sami raguwar magana ta PDYN mRNA a cikin jigon amygdala na ɗan adam bayan mutuwa na periamygdaloid cortex (PAC) a cikin masu cin zarafin tabar heroin da batutuwa na MDD.Hakazalika da mutane, berayen da tabar heroin ke sarrafa kansu na tsawon lokaci sun rage bayyanar Pdyn mRNA a cikin PAC a wani lokaci mai alaƙa da mummunan yanayi.Amfani da in vivo fasahar hoto mai aiki DREAMM (Taswirar taswirar rayuwa ta DREADD, inda DREADD ke nuna masu karɓar masu ƙira waɗanda ke kunna su ta hanyar magungunan ƙira), mun gano cewa zaɓin hana Pdyn-bayyana neurons a cikin bera PAC yana haɓaka ayyukan rayuwa a cikin amygdala mai tsayi, wanda babban maɓalli ne na tsarin damuwa na ƙwaƙwalwa na extrahypothalamic.A cikin layi daya, hana Pdyn na musamman na PAC ya haifar da sauye-sauyen yanayi masu alaƙa da cutarwa.Gabaɗaya, binciken mu na fassarar yana goyan bayan rawar aiki don Pdyn mai rauni a cikin PAC a cikin cin zarafi ta hanyar kunna damuwa da mummunan tasirin neurocircuitry da ke tattare da raunin jaraba.