Kayayyaki

Abubuwan muhalli, irin su ma'aunin abinci mai gina jiki na macronutrient, na iya yin tasiri mai zurfi akan haɗarin ciwon sukari da ciwo na rayuwa.A cikin binciken da muke ciki mun nuna yadda guda ɗaya, mai sauƙi mai sauƙi - leucine - zai iya canza juriya na insulin ta hanyar yin aiki akan kyallen takarda da yawa kuma a matakai masu yawa na metabolism.An sanya beraye kan abinci na al'ada ko mai yawa (HFD).An ninka leucine na abinci sau biyu ta ƙari ga ruwan sha.mRNA, furotin da cikakkun bayanan martaba na metabolomic an tantance su a cikin manyan kyallen jikin insulin da jini, kuma an danganta su da canje-canje a cikin glucose homeostasis da siginar insulin.Bayan makonni 8 akan HFD, mice sun haɓaka kiba, hanta mai kitse, canje-canje masu kumburi a cikin adipose nama da juriya na insulin a matakin phosphorylation IRS-1, da kuma sauye-sauye a cikin bayanan metabolomic na amino acid metabolites, tsaka-tsakin zagaye na TCA, glucose da cholesterol metabolites. , da fatty acids a cikin hanta, tsoka, mai da jini.Sau biyu leucine na abinci ya haifar da rashin daidaituwa da yawa kuma ya haifar da ingantaccen haɓakawa a cikin juriyar glucose da siginar insulin ba tare da canza abincin abinci ko riba mai nauyi ba.Ƙara yawan leucine na abinci yana da alaƙa da raguwa a cikin steatosis na hanta da raguwar kumburi a cikin nama mai adipose.Waɗannan canje-canjen sun faru duk da haɓakar phosphorylation mai haɓaka insulin na p70S6 kinase yana nuna haɓakar kunna mTOR, al'amarin da aka saba danganta da juriya na insulin.Waɗannan bayanai sun nuna cewa ƙananan canje-canje a cikin yanayi guda ɗaya na muhalli/na gina jiki na iya canza hanyoyin rayuwa da yawa da kuma sigina da kuma gyara HFD da ke haifar da ciwo na rayuwa ta hanyar aiki a matakin tsari akan kyallen takarda da yawa.Waɗannan bayanan kuma suna ba da shawarar cewa haɓaka leucine na abinci na iya ba da haɗin kai a cikin sarrafa juriyar insulin da ke da alaƙa da kiba.