Kayayyaki

Ƙara yawan damuwa na oxidative a ƙarƙashin yanayin hyperglycemic, ta hanyar hulɗar AGEs tare da masu karɓa na RAGE da kuma ta hanyar kunna siginar sakonni ta interleukin, an ruwaito a cikin ciwon daji.Ana binciken gyare-gyaren sunadaran don rawar da suke takawa a cikin ci gaba da ci gaba da ciwon daji da kuma mayar da martani na autoantibody a kansu yana samun sha'awa a matsayin bincike don gano cutar da wuri.Wannan binciken ya bincika canje-canje a cikin histone H1 akan gyare-gyare ta hanyar methylglyoxal (MG) da abubuwan da ke tattare da shi a cikin auto-immunopathogenesis na ciwon daji.gyare-gyaren tarihi ya nuna gyare-gyare a cikin ragowar kayan ƙanshi, canza yanayin microenvironment na tyrosine, haɗin giciye na intermolecular da tsarar AGEs.Ya nuna abin rufe fuska na facin hydrophobic da canjin hypsochromic a cikin takamaiman haske na ANS.MG da ƙarfi oxidized histone H1 yana haifar da tarawar carbonyls masu amsawa.Ma'aunin CD na UV mai nisa ya nuna haɓakawar di-carbonyl na haɓaka tsarin alpha da ƙaddamar da ƙirar beta;da kuma nazarin zafin jiki (Tm) sun tabbatar da kwanciyar hankali na yanayin zafi na tarihin da aka gyara.Binciken FTIR ya nuna motsi na amide I band, tsarar ƙungiyar carboxyethyl da rawar N-CA a cikin tarihin da aka gyara.Binciken LCMS ya tabbatar da samuwar Nε- (carboxyethyl) lysine da nazarin microscopic na lantarki ya nuna nau'in haɓakar amorphous.Tarihin da aka gyara ya nuna canjin haɗin gwiwa tare da DNA.H1 da aka gyara ya haifar da manyan ƙwayoyin rigakafi na titre a cikin zomaye da nau'in nau'in nau'in nau'in nau'in zomaye na IgG wanda aka yiwa rigakafi tare da ingantaccen H1 yana nuna takamaiman ɗaure tare da immunogen sa a cikin binciken Western Blot.IgG keɓe daga sera na marasa lafiya da ciwon huhu, prostate ciwon daji, nono da kuma ciwon daji na kai da kuma wuyansa yankin ya nuna mafi kyau ganewa ga neo-epitopes a kan modified histone, nuna gaban circulating autoantibodies a cikin ciwon daji.Tun da rahotanni sun ba da shawarar haɗin gwiwa tsakanin AGE-RAGE axis da carcinogenesis, glycoxidation na histone H1 da immunogenicity ta buɗe hanyoyi don fahimtar rawar da glycoxidatively lalata sunadarai na nukiliya a cikin ciwon daji.