Kayayyaki

Tasirin ƙwayoyin rigakafi a cikin maganin Pseudomonas aeruginosa ciwon huhu ya ragu a sakamakon yaduwar juriya na ƙwayoyin cuta.Kasancewar tsarin sadarwa na kwayan cuta, kamar sanin ƙima, ya ba da sabbin damar jiyya.Lactonases da kyau yana kashe acyl-homoserine lactone-based quorum ƙwararrun ƙwayoyin cuta, yana haifar da waɗannan enzymes azaman yuwuwar sabbin magungunan anti-Pseudomonas waɗanda za a iya kimantawa a cikin ciwon huhu. Manufar binciken yanzu shine kimanta ikon lactonase da ake kira SsoPox-I don ragewa. Mutuwar bera P. aeruginosa pneumonia.Don tantance SsoPox-I-matsakaici quorum quenching, mun fara auna aikin virulence gene lasB, da kira na pyocianin, da proteolytic aiki na kwayan cuta dakatar da samuwar biofilm na wani biofilm. PAO1 iri girma a gaban lactonase.A cikin wani m m model na P. aeruginosa ciwon huhu a cikin berayen, mun kimanta sakamakon farkon ko jinkirta jiyya na intracheal tare da SsoPox-I akan mace-mace, kwayoyin cutar huhu da lalacewar huhu. , pyocianin kirar, aikin proteolytic da samuwar biofilm.Yin amfani da farko na SsoPox-I ya rage yawan mace-mace na berayen tare da ciwon huhu mai tsanani daga 75% zuwa 20%.Lalacewar huhu na tarihi ya ragu sosai amma ba a canza adadin ƙwayoyin cutar huhu ta hanyar magani ba.An danganta jinkirin jinkiri tare da raguwar mace-mace maras muhimmanci.Wadannan sakamakon suna nuna tasirin kariya na lactonase SsoPox-I a cikin P. aeruginosa ciwon huhu da kuma bude hanyar yin amfani da magani na gaba.