Doxorubicin hydrochloride CAS: 25316-40-9 99% Orange-ja Crystalline foda
| Lambar Catalog | Saukewa: XD90367 |
| Sunan samfur | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Tsarin kwayoyin halitta | C27H29NO11·HCl |
| Nauyin Kwayoyin Halitta | 579.98 |
| Bayanin Ajiya | 2 zuwa 8 ° C |
| Harmonized Tariff Code | Farashin 29419000 |
Ƙayyadaddun samfur
| RuwaAbun ciki | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Mai narkewa a cikin: ruwa, methanol da isotonic NaCl (aq).Rashin ƙarfi a cikin chloroform da sauran kaushi na halitta. |
| Abubuwa masu alaƙa | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Assay | 99% |
| Ragowar Magani | Acetone da barasa: ≤2.5% / acetone: ≤0.5% / methanol: ≤500ppm |
| Duk Wasu Najasa | 0.5% |
| Jimlar ƙazanta | ≤ 2.0% |
| Crystallinity | Ya dace da USP |
| Bayyanar | Orange-ja Crystalline foda |
| Ganewa | HPLC |
Marasa lafiya tare da P-glycoprotein da HER2/neu (HER2) mai karɓa-overexpressing ciwon nono yawanci suna da mummunan sakamako na asibiti.Duk da haka, babu wani layi na nono da ke samuwa a kasuwa wanda ke da HER2/P-glycoprotein sau biyu mai kyau, wanda ya iyakance bincike a cikin wannan filin.Muna bayar da rahoto game da ci gaba da kuma halayyar ƙananan layi na miyagun ƙwayoyi daga nono mai kyau na HER2. Layin kwayar cutar kansa ta hanyar daidaitawar kaset na ATP-binding cassette (ABC) rukunin B memba na 1 (ABCB1) wanda ke ɓoye P-glycoprotein.ABCB1 matakan maganganun kwayoyin sun kasance mafi girma bayan kamuwa da cuta, wanda ya haifar da haɓakar 40 a P-glycoprotein. magana.Abin sha'awa shine, canjin ABCB1 kuma ya haifar da karuwa kadan a cikin kwayoyin HER2 da matakan furotin.Canja wurin ABCB1 ya ƙãra matakan maganganun P-glycoprotein sosai. Hanyar da aka yi amfani da ita a nan don bunkasa wannan layin tantanin halitta ya dace da sauri, barga shigar da P-glycoprotein-matsakaicin magungunan ƙwayoyi idan aka kwatanta da tr aditional hanyoyin.Gwajin cytotoxicity na in vitro yana nuna wannan layin tantanin halitta yana da juriya ga nau'ikan magungunan chemotherapeutic da yawa.
