Kayayyaki

An ba da shawarar kumburin hanyar iska na yau da kullun da gyare-gyare, gami da fibrosis a matsayin masu ba da gudummawa mai mahimmanci ga ilimin cututtukan asma.Binciken da ya gabata game da fibrosis na iska an yi shi ne musamman a cikin ƙananan ƙwayar asthmatics da matsakaici a matakin "ginshiƙan ƙasa" (SBM) na subepithelial.An tsara binciken na yanzu don kimanta babban kauri na SBM na iska da ƙaddamarwar ƙwayar cuta na submucosal, kamar yadda aka auna ta hanyoyi daban-daban na lalata collagen, a cikin biopsies na endobronchial daga 17 mai tsanani, matsakaicin matsakaici, da bakwai masu asthmatics, da kuma batutuwa takwas na al'ada.An kuma bincika ƙwayoyin eosinophils da canza yanayin girma-beta (TGF-beta) immunoreactivity.Babu wani bambance-bambancen ƙididdiga a cikin kauri na SBM, ƙaddamarwar ƙwayar ƙwayar cuta ta submucosal, lambobin eosinophil, ko ƙwayoyin cuta masu kyau na TGF-beta tsakanin ƙungiyoyi uku na asthmatics da abubuwan sarrafawa na yau da kullun.Sai kawai lokacin da aka bincika duk masu ciwon asthmatics (n = 33) tare, an lura da SBM mai kauri mai kauri (p = 0.04), kamar yadda aka kimanta ta nau'in immunostaining na collagen na III, idan aka kwatanta da abubuwan sarrafawa na yau da kullun.Duk da wannan bambance-bambance, ba a sami bambance-bambance masu mahimmanci a cikin adadin ƙaddamarwar ƙwayar ƙwayar cuta ta submucosal da adadin eosinophils ko TGF-beta da ke bayyana sel yayin kwatanta jimlar asthmatics da batutuwa na al'ada.Bugu da ƙari, ba a sami mahimmiyar alaƙa tsakanin shigar collagen da ƙididdigar eosinophil, matakin magana TGF-beta, FEV1, ko tsawon lokacin asma.Wadannan sakamakon sun nuna cewa ko da yake ƙara yawan shigar da collagen a cikin SBM a babban matakin jirgin sama hali ne na asma, bazai bayyana bambance-bambance a cikin tsanani na asma ba.