Kayayyaki

Islet amyloid polypeptide (IAPP; wanda kuma aka sani da amylin) yana da alhakin samuwar tsibiri amyloid a cikin nau'in ciwon sukari na 2, kuma an yi imanin cewa guba ta haifar da IAPP tana ba da gudummawa ga asarar ƙwayar β-cell mai alaƙa da ƙarshen matakan nau'in ciwon sukari na 2.Samuwar amyloid na Islet na iya taka rawa wajen gazawar dasawa bayan dasawa.Ana samar da IAPP azaman prohormone, pro-islet amyloid polypeptide (proIAPP), kuma ana sarrafa shi a cikin ɓangarorin ɓoye na ƙwayoyin β-pancreatic.Ana samun nau'ikan nau'ikan proIAPP da aka sarrafa su a cikin ajiyar amyloid;Mafi shahara shine matsakaicin saura 48, proIAPP (1-48), wanda ya haɗa da N-terminal pro-extension, amma an sarrafa shi yadda yakamata a C-terminus.Ayyukan da ba su cika ba na iya taka rawa a cikin samuwar amyloid na tsibirin ta hanyar haɓaka hulɗa tare da sulfated proteoglycans na matrix extracellular, wanda, bi da bi, yana inganta samuwar amyloid.Mun nuna cewa fuchsin acid (3- (1--amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic acid), mai sauƙi. sulfonated triphenyl methyl derivative, babban mai hana samuwar amyloid ta tsakiyar proIAPP(1-48).Mafi rikitarwa triphenyl methane wanda ya samo asali mai sauri FCF {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino] phenyl] (4-hydroxy-2-sulfophenyl) methylidene] -1-cyclohexa -2,5-dienylidene] - [(3-sulfophenyl) methyl] azanium} kuma yana hana amyloid samuwar ta IAPP da matsakaicin sarrafawa na proIAPP.Dukansu mahadi suna hana samuwar amyloid ta hanyar gaurayawan matsakaicin proIAPP da samfurin glycosaminoglycan heparan sulfate.Acid fuchsin kuma yana hana samuwar amyloid mai matsakaicin glycosaminoglycan ta IAPP balagagge.Ikon hana amyloid samuwar ba kawai saboda mahadi da ake sulfonated, tun da sulfonated inhibitor na amyloid-β, tramiprosate, ba mai hana amyloid samuwar ta proIAPP (1-48).