Kayayyaki

RasGrf1 da RasGrf2 abubuwa ne masu mu'amala da mammalian guanine nucleotide waɗanda ke iya kunna takamaiman Ras ko Rho GTPases.Kwayoyin halittar RasGrf an fi bayyana su a cikin tsarin juyayi na tsakiya, kodayake ƙayyadaddun bayanin kowane wuri na iya faruwa a wani wuri.RasGrf1 wani nau'in halitta ne wanda aka bayyana a wajen uba, wanda aka buga wanda aka bayyana bayan haihuwa.Sabanin haka, RasGrf2 ba a buga shi ba kuma yana nuna ƙirar magana mai faɗi.Ana iya gano nau'ikan isoform iri-iri na kwayoyin halittar biyu kuma ana iya gano su a cikin mahallin salon salula daban-daban.Sunadaran RasGrf suna baje kolin sifofi da aka haɗa ta yankuna da yawa waɗanda suka haɗa da CDC25H da DHPH motifs waɗanda ke da alhakin haɓaka musanya GDP/GTP, bi da bi, akan maƙasudan Ras ko Rho GTPase.Yankuna daban-daban suna da mahimmanci don ayyana ayyukan masu musayar su na ciki da kuma daidaita ƙayyadaddun ayyukan aikinsu don haɗa sigina daban-daban na sama zuwa maƙasudai daban-daban na ƙasa da martanin salula.Duk da ilimin halittarsu, RasGrf1 da RasGrf2 suna nuna bambance-bambancen ƙayyadaddun ƙayyadaddun manufa da ayyukan aiki marasa daidaituwa a cikin mahallin sigina iri-iri da ke da alaƙa da haɓakar tantanin halitta da rarrabuwa da haɓakar neuronal da amsawa ko filastik synaptic.Duk da yake duka RasGrfs suna kunnawa ta hanyar masu karɓar glutamate, masu karɓa na G-protein-coupled ko canje-canje a cikin ƙwayar calcium na ciki, kawai RasGrf1 ne aka ruwaito cewa LPA, cAMP, ko agonist- kunna Trk da cannabinoid masu karɓa.Binciken nau'ikan nau'ikan ƙwanƙwasa daban-daban ya gano takamaiman gudummawar aikin RasGrf1 a cikin hanyoyin ƙwaƙwalwar ajiya da koyo, ɗaukar hoto, sarrafa haɓakar bayan haihuwa da girman jiki da aikin β-cell pancreatic da glucose homeostasis.Don RasGrf2, takamaiman matsayi a cikin yaduwar lymphocyte, amsawar siginar T-cell da lymphomagenesis an bayyana su.