Heparin sodium Cas: 9041-08-1 fari ko kusan fari, hygroscopic foda
| Lambar Catalog | XD90184 |
| Sunan samfur | Heparin sodium |
| CAS | 9041-08-1 |
| Tsarin kwayoyin halitta | Saukewa: C12H17NO20S3 |
| Nauyin Kwayoyin Halitta | 591.45 |
| Bayanin Ajiya | 2 zuwa 8 ° C |
| Harmonized Tariff Code | Farashin 30019091 |
Ƙayyadaddun samfur
| Bayyanar | fari ko kusan fari, hygroscopic foda |
| Asay | 99% |
| Takamaiman juyawa | Kayan busassun kada ya zama ƙasa da +50 ° |
| pH | 5.5 - 8.0 |
| Bacterial endotoxin | Kasa da 0.01 IU ta Ƙungiyar Heparin ta Duniya |
| Ragowar sauran ƙarfi | Dangane da daidaitaccen hanyar ciki tare da ƙididdigar yanki mafi girma, methanol, ethanol, acetone, kuma, bi da bi, 0.3%, 0.5%, ko ƙasa da haka |
| Ragowa akan Ignition | 28.0% -41.0% |
| Sodium | 10.5% -13.5% (bushewar abu) |
| Protein | <0.5% (bushewar abu) |
| Nitrogen | 1.3% -2.5% (bushewar abu) |
| Kayayyakin Nucleotidic | 260nm<0.10 |
| Karfe mai nauyi | ≤ 30pm |
| Tsaftace da launi na bayani | Magani ya zama bayyananne mara launi;Irin su turbidity, ultraviolet-bayyana spectrophotometry, ƙayyadaddun shayarwa a tsawon 640 nm, ba zai wuce 0.018 ba;Irin su launi, idan aka kwatanta da daidaitaccen ruwa mai launin rawaya, ba zai yi zurfi ba |
| Abubuwa masu alaƙa | Jimlar dermatan sulfate da chondroitin sulfate: bai wuce sararin da ya dace ba a cikin chomatogram da aka samu tare da maganin tunani.Duk wani ƙazanta: babu kololuwa banda ganiya saboda determatan sulfate da chondroitin sulfate da aka gano. |
| anti-FXa/anti-FIa | 0.9-1.1 |
| Liquid chromatography | Maganin samfurin sarrafawa a cikin chromatogram, dermatan sulfate (tsawo mafi girma da heparin da dermatan sulfate) tsakanin tsayin tsayin kwari ba zai zama ƙasa da 1.3 ba, wanda aka samu tare da maganin gwajin yayi kama da lokacin riƙewa da siffar zuwa babban kololuwa a cikin chromatogram da aka samu tare da bayani bayani.Lokacin riƙewa ba zai wuce 5% ba |
| Nauyin kwayoyin halitta da rarraba nauyin kwayoyin halitta | Matsakaicin nauyin kwayoyin halitta ya kamata ya zama 15000 - 19000. Nauyin kwayoyin fiye da 24000 na sa ba zai zama mafi girma fiye da 20% ba, nauyin kwayoyin halitta na 8000 - 16000 na nauyin kwayoyin halitta na 24000 - 16000 na rabo kada ya zama ƙasa. fiye 1 |
| bushe nauyi asarar | ≤ 5.0% |
| Micro kwayoyin halitta | Jimlar ƙidayar aerobic mai yiwuwa: <10³cfu/g .Fungi/yisti <10²cfu/g |
| anti-factor IIa | ≥180 IU/mg |
Heparin, Sodium gishiri shine heparin polymer wanda ke samar da babban tasirin sa na anticoagulant ta hanyar kunna antithrombin.Wannan kunnawa yana haifar da canji a cikin ATIII kuma yana ba da damar haɓaka sassauci a cikin madaukin rukunin yanar gizon sa.Heparin shine glycosaminoglycan sulfated wanda aka sani don hana clots.Heparin, Sodium Salt shima mai kunnawa RyR da ATIII ne.
Jiki da sinadarai Properties: Heparin sodium fari ne ko kusan fari foda, wari, hygroscopic, mai narkewa a cikin ruwa, insoluble a Organic kaushi kamar ethanol da acetone.Yana da mummunan caji mai ƙarfi a cikin maganin ruwa kuma yana iya haɗawa tare da wasu cations don samar da hadaddun kwayoyin halitta.Maganin ruwa mai ruwa sun fi kwanciyar hankali a pH 7.
Anticoagulant: Heparin sodium anticoagulant ne, mucopolysaccharide, sodium gishiri na glucosamine sulfate cire daga hanji mucosa na aladu, da shanu da tumaki, da kuma boye da mast Kwayoyin a cikin jikin mutum.Kuma a zahiri ya wanzu a cikin jini.Heparin sodium yana da ayyuka na hana haɓakar platelet da lalata, yana hana jujjuyawar fibrinogen zuwa fibrin monomer, hana samuwar thromboplastin da tsayayya da thromboplastin da aka kafa, yana hana juyawar prothrombin zuwa thrombin da antithrombin.Heparin sodium na iya jinkirta ko hana coagulation jini duka a cikin vitro da in vivo.Tsarin aikinsa yana da rikitarwa sosai kuma yana shafar hanyoyin haɗin gwiwa da yawa a cikin tsarin coagulation.Ayyukansa sune: ① hana samuwar thromboplastin da aikin thromboplastin, don haka yana hana prothrombin zama thrombin;② a cikin mafi girma da yawa, yana da tasirin hana thrombin da sauran abubuwan haɗin gwiwa, hana fibrinogen daga zama Fibrin Protein;③ na iya hana tarawa da lalata platelet.Bugu da ƙari, tasirin anticoagulant na heparin sodium yana da alaƙa da mummunan cajin sulfate radical a cikin kwayoyin sa.Abubuwan da aka caje da kyau kamar su protamine ko toluidine blue na iya kawar da mummunan cajin sa, don haka yana iya hana maganin sa.tasiri.Saboda heparin na iya kunnawa da sakin lipoprotein lipase a cikin vivo, hydrolyze triglyceride da low-density lipoprotein na chylomicrons, don haka yana da tasirin hypolipidemic.Ana iya amfani da sodium na Heparin don magance cututtukan thromboembolic mai tsanani, wanda aka watsar da coagulation na intravascular (DIC).A cikin 'yan shekarun nan, an gano heparin yana da tasirin cire lipids na jini.Ciki ko alluran ciki mai zurfi (ko allurar subcutaneous), raka'a 5,000 zuwa 10,000 kowane lokaci.Heparin sodium ba shi da guba kuma yanayin zub da jini na kwatsam shine mafi mahimmancin haɗarin wuce gona da iri na heparin.Ba shi da tasiri a baki, dole ne a yi shi ta hanyar allura.Allurar cikin jiki ko kuma allurar subcutaneous yana da ban haushi, a wasu lokuta halayen rashin lafiyan na iya faruwa, kuma yawan wuce gona da iri na iya haifar da kama zuciya;lokaci-lokaci asarar gashi da gudawa.Bugu da ƙari, har yanzu yana iya haifar da karaya ba tare da bata lokaci ba.Yin amfani da dogon lokaci na iya haifar da thrombosis, wanda zai iya zama sakamakon ragewar anticoagulase-III.Heparin sodium an hana shi a cikin marasa lafiya tare da yanayin zub da jini, hanta mai tsanani da gazawar koda, hauhawar jini mai tsanani, hemophilia, hemorrhage na intracranial, ulcer na ciki, mata masu ciki da bayan haihuwa, ciwace-ciwacen visceral, rauni da tiyata.
Amfani: Binciken biochemical, ana amfani dashi don hana jujjuyawar prothrombin zuwa thrombin, tare da tasirin antithrombotic.
Yana amfani da: Heparin sodium magani ne na mucopolysaccharide biochemical wanda aka samo daga mucosa na hanji na porcine tare da aikin anticoagulant mai ƙarfi.Mclcan ya gano mucopolysaccharide heparin na mata a cikin hanta daga karnuka yayin da yake nazarin tsarin daskarewar jini.Brinkous et al.An tabbatar da cewa heparin yana da aikin anticoagulant.Bayan da aka yi amfani da heparin a matsayin maganin rigakafi a cikin aikace-aikacen asibiti a karon farko, ya sami kulawa daga ko'ina cikin duniya.Kodayake yana da tarihin fiye da shekaru 60 a cikin amfani da asibiti, babu wani samfurin da zai iya maye gurbinsa gaba daya zuwa yanzu, don haka har yanzu yana daya daga cikin mafi mahimmancin magungunan anticoagulant da antithrombotic biochemical.Yana da fa'idar amfani a magani.Ana amfani da shi don magance myocardial infarction da pathogenic hepatitis.Ana iya amfani dashi a hade tare da ribonucleic acid don ƙara yawan tasirin hanta na hepatitis B. Ana iya amfani dashi tare da chemotherapy don hana thrombosis.Yana iya rage lipids na jini da inganta aikin rigakafi na ɗan adam.shima yana da wani tasiri.Ƙananan nauyin kwayoyin heparin sodium yana da aikin anticoagulant factor Xa.Nazarin Pharmacodynamic ya nuna cewa ƙananan ƙwayar heparin sodium yana da tasiri mai hanawa akan samuwar thrombus da arteriovenous thrombosis a cikin vivo da in vitro, amma yana da tasiri kadan akan tsarin coagulation da fibrinolysis, wanda ya haifar da sakamako na antithrombotic.zubar jini ya ragu.Unfractioned heparin cakude ne na daban-daban amino glucan glycosides wanda zai iya jinkirta ko hana jini coagulation a cikin vitro da a vivo.Na'urar rigakafin ta yana da rikitarwa, kuma yana da tasiri a kan dukkan bangarorin coagulation.Ciki har da hana prothrombin cikin thrombin;hana ayyukan thrombin;hana canza fibrinogen zuwa fibrin;hana haɓakar platelet da lalata.Har yanzu Heparin na iya rage yawan lipids na jini, ƙananan LDL da VLDL, ƙara HDL, canza dankon jini, kare ƙwayoyin endothelial na jijiyoyin jini, hana atherosclerosis, inganta yaduwar jini, da inganta yanayin jini.
Amfani: Binciken Biochemical, don hana juyar da prothrombin zuwa thrombin.
Amfani: Ana amfani da shi don jinkirta da hana zubar jini
