Kayayyaki

Ivermectin (Cardomec, Eqvalan, Ivomec) cakuda ne na 22,23-dihydro abubuwan da aka samo na avermectins B1a da B1b wanda aka shirya ta hanyar hydrogenation mai ƙarfi.Avermectins memba ne na dangi na hadadden maganin rigakafi wanda aka samar ta hanyar fermentation tare da nau'in Streptomycesavermitilis.Binciken nasu ya samo asali ne daga babban binciken al'adu don magungunan anthelmintic daga albarkatun ƙasa.Ivermectin yana aiki a cikin ƙananan sashi a kan nau'ikan nematodes da arthropods waɗanda ke lalata dabbobi.
Ivermectin ya sami nasarar amfani da shi sosai a likitan dabbobi a Amurka da ƙasashe da yawa a duk faɗin duniya don sarrafa endoparasites da ectoparasitesin dabbobin gida.An samo shi mai tasiri don maganin onchocerciasis ("makanta kogi") a cikin mutane, wata muhimmiyar cuta da ta haifar da roundwormOncocerca volvulus, wadda ta fi yawa a Yammacin Afirka ta Tsakiya, Gabas ta Tsakiya, da Kudancin Amirka da Tsakiyar Amirka.Ivermectin yana lalata microfilariae, rashin girma. nau'in nematode, wanda ke haifar da fata da nodules na nama waɗanda ke da halayyar kamuwa da cuta kuma suna iya haifar da makanta. Yana kuma hana sakin microfilariae ta tsutsotsi na manya da ke zaune a cikin gidan.Nazarin kan tsarin aikin ivermectin ya nuna cewa yana toshe watsawar interneuron-motor neuron a cikin nematodes ta hanyar ƙarfafa sakin na'urar hanawa ta GABA.

Ivermectin yana da faffadan ayyuka a cikin cewa zai iya shafar nematodes, kwari, da acarine parasites.Yana da magani na zabi a cikin onchocerciasis kuma yana da amfani sosai a maganin wasu nau'in filariasis, strongyloidiasis, ascariasis, loiasis, da tsutsa masu ƙaura.Har ila yau yana aiki sosai a kan mites iri-iri.Ita ce maganin da aka zaɓa a cikin kula da mutanen da suka kamu da Onchocerca volvulus, suna aiki a matsayin maganin microfilaricidal akan larvae da ke zaune a fata (microfilaria).Jiyya na shekara-shekara na iya hana makanta daga ocular onchocerciasis.Ivermectin yana da tasiri a fili fiye da diethylcarbamazine a cikin bancroftian filariasis, kuma yana rage microfilaremia zuwa kusa da matakan sifili.A cikin filariasis na brugian diethylcarbamazine-jawowa zai iya zama mafi girma.Hakanan ana amfani da ita don magance tsutsa masu ƙaura da kuma yaduwan strongyloidiasis.Amintaccen amfani da shi a cikin ciki ba a tabbatar da cikakke ba.