Kayayyaki

Muhimmancin juriya na ƙananan ƙwayoyin cuta tare da rashin sababbin magungunan ƙwayoyin cuta ya karu da sha'awar ci gaban peptides na antimicrobial (AMPs) a matsayin magungunan novel.A cikin wannan binciken, mun kimanta ayyukan antimicrobial na gajerun peptides guda biyu, wato, RRIKA da RR.Waɗannan peptides sun baje kolin aikin rigakafin ƙwayoyin cuta mai ƙarfi a kan Staphylococcus aureus, kuma tasirin antimicrobial ɗinsu ya inganta sosai ta hanyar ƙara amino acid guda uku a cikin tashar C, wanda sakamakon haka ya haɓaka amphipathicity, hydrophobicity, da cajin net.Bugu da ƙari, RRIKA da RR sun nuna wani tasiri mai mahimmanci da sauri na ƙwayoyin cuta a kan asibiti da kuma maganin kwayoyin cutar Staphylococcus, ciki har da methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA) , S. aureus mai jure layin linezolid, da kuma Staphylococcus epidermidis mai jurewa methicillin.Ya bambanta da yawancin AMPs na halitta, RRIKA da RR suna riƙe da aikin magaji a gaban yawan adadin NaCl da MgCl2.Dukansu RRIKA da RR sun haɓaka kashe lysostaphin fiye da ninki 1,000 kuma sun kawar da MRSA da VRSA a cikin 20 min.Bugu da ƙari kuma, peptides da aka gabatar sun kasance mafi girma wajen rage masu bin biofilms na S. aureus da S. epidermidis idan aka kwatanta da sakamakon da maganin rigakafi na al'ada.Abubuwan da muka gano sun nuna cewa tasirin staphylocidal na peptides ɗinmu ya kasance ta hanyar ɓarnawar membrane na kwayan cuta, wanda ke haifar da zubewar abubuwan cytoplasmic da mutuwar tantanin halitta.Bugu da ƙari kuma, peptides ba su da guba ga ƙwayoyin HeLa a 4- zuwa 8-ninka yawan adadin ƙwayoyin cuta.Ayyukan antimicrobial masu ƙarfi da gishiri marasa ƙarfi na waɗannan peptides suna gabatar da ɗan takarar warkewa mai ban sha'awa don maganin cututtukan S. aureus masu jure wa ƙwayoyi da yawa.