Kayayyaki

Don bincika sababbin magungunan maganin ciwon daji na platinum waɗanda suka bambanta da tsari da yanayin hulɗar cisplatin na gargajiya ta hanyar samar da intrastrand 1,2 GpG adduct na bifunctional, an yi nazarin platinum + DNA na monofunctional tare da hulɗar da ba ta dace ba.An ba da rahoton cewa wakilai na platinum (II) na tushen testosterone na monofunctional suna gabatar da babban aikin maganin ciwon daji.Bugu da ƙari, an kuma gano cewa ma'aikatan platinum na tushen testosterone na iya haifar da helix na DNA don yin tasiri mai mahimmanci da kuma lankwasa akan ma'aikatan platinum da ba na testosterone ba.Duk da haka, hanyoyin haɗin gwiwar waɗannan wakilai na platinum tare da DNA a matakin atomic ba su bayyana ba har yanzu. A cikin aikin yanzu, mun yi amfani da simintin gyare-gyare na kwayoyin halitta (MD) da kuma ƙididdigar ƙididdiga na DNA don nazarin abubuwan da ke tattare da DNA na kwayoyin testosterone- tushen platinum+DNA, ingantaccen platinum+DNA na tushen testosterone da platinum+DNA da ba na testosterone ba.Sakamakon ya nuna cewa hulɗar tsaka-tsakin ingantacciyar ma'auni na platinum mai sassaucin ra'ayi tare da kwayoyin DNA na iya haifar da ɓarna mafi girma na DNA fiye da hulɗar fuskar fuska na ma'auni na tushen platinum na testosterone tare da kwayoyin DNA.Ƙarin bincike don ma'aikacin platinum wanda ba na testosterone ba ya nuna abin da ya faru na canji maras muhimmanci na DNA conformation saboda rashin testosterone ligand a cikin irin wannan wakili.Dangane da bincike na DNA Dynamic analysis, DNA tushe motsi da suka shafi DNA tsagi canje-canje da kuma hydrogen bond halakar da DNA tushe nau'i-nau'i an kuma tattauna a cikin wannan aiki. ingantaccen platinum + DNA na tushen testosterone, wanda ya bambanta da hulɗar tsagi-fuskar da aka haifar ta hanyar haɗin gwiwa mai ƙarfi a cikin wakili na platinum na tushen testosterone.Binciken da aka yi a yanzu yana ba da bayanai masu amfani na tsarin DNA wanda ya shafi hadadden platinum na testosterone a matakin atomic.