Kayayyaki

Eucine-rich repeat kinase 2 (LRRK2) maye gurbi shine mafi yawan sanannun sanadin cutar Parkinson (PD).Siffofin asibiti na LRRK2 PD ba su da bambanci daga PD idiopathic, tare da tarawar α-synuclein da / ko tau da / ko ubiquitin a cikin tarawar intraneuronal.Wannan yana nuna cewa LRRK2 shine mabuɗin don fahimtar aetiology na cuta.Ko da yake asarar-aiki ba ya bayyana a matsayin hanyar da ke haifar da PD a cikin marasa lafiya na LRRK2, ba a bayyana yadda wannan furotin ke magance guba ba.A cikin wannan binciken, mun bayar da rahoton cewa LRRK2 overexpression a cikin sel da kuma a cikin vivo yana lalata ayyukan hanyar ubiquitin-proteasome, kuma wannan yana haifar da tarin nau'i-nau'i daban-daban tare da LRRK2 overexpression.Mun nuna cewa wannan ba a shiga tsakani ta manyan tarukan LRRK2 ko rarraba ubiquitin zuwa tara.Mahimmanci, ba a ganin irin wannan rashin daidaituwa tare da wuce gona da iri na furotin LRRK1.Bayanan namu sun nuna cewa LRRK2 yana hana sharewar proteasome substrate s sama da ayyukan proteasome catalytic, yana fifita tarin sunadaran da samuwar jimillar.Don haka, muna samar da hanyar haɗin kwayoyin halitta tsakanin LRRK2, sanannen sanadin PD, da kuma nau'in nau'in furotin da aka bayyana a baya.