Kayayyaki

Hyperkalemia yayin hana tsarin renin-angiotensin-aldosterone (RAAS-I) na iya hana mafi kyawun sashi.Zaɓuɓɓukan jiyya sun haɗa da sodium polystyrene sulfonate potassium daure resins, amma aminci da damuwa akwai damuwa, gami da haɗin gwiwar colonic necrosis (CN).An yi nazarin ma'auni na madadin, amma ba a ƙididdige yawan amfani da farashi ba.Mun yi wani bincike mai mahimmanci na masu amfani da marasa lafiya ≥ 18 shekaru masu karɓar RAAS-I na yau da kullum, tare da tarihin hyperkalemia ko ciwon koda, wanda aka wajabta ko dai sodium polystyrene sulfonate. ko ka'idar "magungunan X" mai ɗaure guduro don hyperkalemia na kullum.An samo bayanai daga littattafan da ake da su.Mun yi amfani da samfurin nazari na yanke shawara tare da nazarce-nazarce mai yiwuwa na Monte Carlo, daga mahangar masu biyan kuɗi na kiwon lafiya da sararin lokaci na watanni 12.An auna farashi a dalar Amurka.An auna tasirin tasiri a cikin shekarun da aka daidaita masu inganci (QALYs), da haɓaka ƙimar ƙimar ƙimar ƙimar (ICERs) . Drug X ba zai iya kashe sama da $ 10.77 a kowace rana don zama mai tsada ba, a shirye-shiryen biya ( WTP) kofa na $50,000/QALY.A $ 40.00 a kowace kashi na yau da kullun, magani X ya sami ƙimar ƙimar ƙimar ƙimar dala $26,088,369.00 akan kowane QALY da aka samu.Binciken hankali na hanya ɗaya ya nuna sodium polystyrene sulfonate don zama zaɓi mai tsada don abubuwan da suka faru na CN ≤ 19.9%.Iyakoki sun haɗa da bayanan da ba su cika ba game da sakamakon marasa lafiya da rashin bayanan kai tsaye kwatanta sodium polystyrene sulfonate zuwa wasu hanyoyin da za a iya amfani da su.Maɗaukaki bazai zama mai tasiri ba sai dai idan an yi farashi daidai da sodium polystyrene sulfonate.Wannan bincike na iya jagorantar yanke shawara game da ɗaukar wasu wakilai don sarrafa hyperkalemia na yau da kullun, kuma yana ba da shawarar cewa a yi amfani da sodium polystyrene sulfonate azaman iko mai ƙarfi a cikin gwajin asibiti na waɗannan wakilai.