Kayayyaki

Don bincika tasirin man mai a kan emphysema-kamar canje-canje da kuma bayyanar da ƙwayar necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) da mai hana nama na metalloproteinase. -1 (TIMP-9) a cikin lipopolysaccharide (LPS) da aka yi wa ratsan.An raba berayen zuwa iko, dexamethasone (0.3 mg x kg(-1)), da kuma man spearmint (10, 30,100 mg x kg(-1)).An yi wa kowace kungiya magani da salin, dexamethasone, da spearmint na mai na tsawon makonni 4.Sa'an nan kuma an gudanar da jimlar adadin fararen ƙwayoyin jini daban-daban a cikin ruwan lavage ruwa na bronchoalveolar (BALF).Canje-canje na pathologic na nama na huhu kamar tsarin alveolar, kumburin iska, da goblet cell metaplasia an lura da su ta hanyar HE da AB-PAS.An auna ma'anar TNF-alpha, IL-1beta, TIMP-1 da MMP-9. Dukansu spearmint da dexamethasone sun rage lalata alveolus na huhu.Jimillar adadin fararen jini daban-daban a cikin BALF da suka haɗa da neutrophile da lymphocyte na man spearmint 100 mg x kg(-1) da ƙungiyar dexamethasone sun ragu sosai, kuma an hana metaplasia cell na goblet.Dexamethasone yana da tasirin hanawa akan maganganun TNF-alpha, IL-1beta, TIMP-1 da MMP-9.Man mai spearmint 30, 100 mg x kg(-1) ya rage mahimmancin TNF-alpha da IL-1beta bi da bi.Man fetur 10, 30 da 100 mg x kg (-1) ba su da tasiri a kan maganganun TIMP-1, amma zai iya rage yawan magana na MMP-9 a cikin ƙwayoyin huhu. tunda yana inganta lalata alveolar, kumburin huhu, da metaplasia cell gublet.Tsarin na iya haɗawa da rage TNF-alpha, IL-1beta abun ciki da hana wuce gona da iri na matrix metalloproteinase-9 a cikin kyallen huhu.