Kayayyaki

An fara ƙaddamar da Telithromycin a Jamus a matsayin maganin baka na yau da kullun don cututtukan numfashi da suka haɗa da ciwon huhu da aka samu a cikin al'umma, ƙaƙƙarfan ƙwayoyin cuta na mashako na kullum, m sinusitis da tonsillitis/pharyngitis.Wannan abin da aka samu na semisynthetic na macrolide erythromycin na halitta shine ketolide na farko da aka fara kasuwa, sabon nau'in maganin rigakafi wanda ke nuna C3-ketone maimakon ƙungiyar L-cladinose.Zobe mai mambobi 14 na maganin rigakafi yana hana haɗin furotin na kwayan cuta ta hanyar ɗaure zuwa yankuna biyu na sashin 50S na ribosomes na kwayan cuta.Yana nuna aiki mai ƙarfi a cikin vitro akan ƙwayoyin cuta na numfashi na kowa ciki har da Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis da Streptococcus pyogenes da sauran cututtukan cututtuka.Ƙungiyar 3-keto tana ba da ƙarin kwanciyar hankali na acidic da rage ƙaddamar da juriya na macrolide-lincosamide-streptogramin B wanda ake yawan gani tare da macrolides.Sauran C11-C12 carbamate da aka maye gurbin ya bayyana ba kawai don haɓaka alaƙa ga rukunin ɗaurin ribosomal ba amma har ma don daidaita wurin da esterase hydrolysis da guje wa juriya saboda kawar da macrolides daga tantanin halitta ta hanyar famfo mai ɓarna wanda mef gene ya ɓoye a cikin wasu ƙwayoyin cuta. .Telithromycin duka mai hanawa mai gasa ne da madaidaicin CYP3A4.Koyaya, ba kamar macrolides da yawa kamar troleandomycin ba, baya samar da barga mai hana CYP P-450 Fe2+-nitrosoalkane metabolite hadaddun wanda ke da yuwuwar hepatotoxic.Magungunan yana da jurewa da kyau kuma an rarraba su cikin kyallen takarda na huhu, ɓarna na bronchi, tonsils da miya.Ya juya ya zama mai girma sosai a cikin granules azurophil na polymorphonuclear neutrophils don haka yana sauƙaƙe isar da shi zuwa ƙwayoyin phagocytosed.