Kayayyaki

An ƙirƙira firikwensin PH ta hanyar anodically electrodepositing iridium oxide fina-finai (AEIROFs) akan microelectrodes akan kwakwalwan kwamfuta kuma an shafe su da poly(ethyleneimine) (PEI) don kwanciyar hankali na inji.Waɗannan suna nuna babban martani ga Nernstian ga pH daga pH 4.0 zuwa 7.7 a cikin buffer phosphate maras chloride.An lulluɓe saman guntu tare da fibronectin don haɗe-haɗe na sel aortic endothelial porcine (PAECs).An bincika ikon aiki na firikwensin pH don saka idanu kan canje-canjen pH na gida ta hanyar ƙarfafa PAECs tare da thrombin.Sakamakonmu ya nuna cewa thrombin ya haifar da m extracellular acidification na PAECs da rushe fibronectin, haifar da pH na gida don ragewa.Yin amfani da PD98059, mai hana furotin kinase (MAPK) mai kunnawa mitogen, rage yawan acidification na waje da karuwa a cikin pH na gida.Wannan binciken ya nuna cewa firikwensin pH ɗin mu na iya sauƙaƙe bincike na martanin salon salula mai ƙarfi don haɓakawa ta hanyar sa ido kan ainihin lokacin, canje-canjen pH na gida na sel waɗanda ke haɗe zuwa na'urori masu auna firikwensin.