Kayayyaki

Trimethoprim wakili ne na lipophilic kuma mai rauni alkaline pyrimethamine aji bacteriostatic.Farin fari ne ko kusan fari crystalline foda, mara wari, ɗaci, da ɗan narkewa a cikin chloroform, ethanol ko da acetone, amma kusan ba zai iya narkewa cikin ruwa kuma yana narkewa sosai a cikin maganin acetic acid glacial.Yana da nau'in kwayoyin cuta wanda yayi kama da magungunan sulfa, amma tare da tasiri mai karfi na antibacterial.Yana da tasiri mai kyau akan maganin Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, da sauran nau'o'in kwayoyin cutar gram-tabbatacce da korau.Amma ba shi da tasiri a kan cutar Pseudomonas aeruginosa.Matsakaicin mafi ƙarancin inhibitory maida hankali ne sau da yawa ƙasa da 10 MG / L tare da yin amfani da shi kaɗai yana da sauƙi don haifar da juriya na ƙwayoyin cuta, don haka gabaɗaya ba a amfani da shi kaɗai, kuma galibi ana haɗa shi da maganin sulfa don samar da shirye-shiryen fili don maganin cututtukan cututtukan urinary, na hanji. cututtuka, cututtuka na numfashi, dysentery, enteritis, zazzabin typhoid, meningitis, otitis media, meningitis, sepsis da taushi nama.Yana da tasirin maganin typhoid da tasirin paratyphoid wanda bai gaza ampicillin ba;Hakanan ana iya haɗa shi da magungunan sulfa masu dogon lokaci don rigakafi da maganin cutar malaria mai jure wa maganin.

Babban ka'idar anti-bacterial na trimethoprim shine tsoma baki tare da folate metabolism a cikin kwayoyin cuta.Babban tsarin aikin shine zaɓin hana ayyukan dihydrofolate reductase a cikin ƙwayoyin cuta ta yadda ba za a iya rage dihydrofolate zuwa tetrahydrofolate ba.Tun da kira na folic acid shine babban ɓangare na biosynthesis na nucleic acid, sabili da haka samfurin yana hana ƙwayoyin nucleic acid da sunadarai.Haka kuma, daurin dauri na trimethoprim (TMP) zuwa kwayoyin dihydrofolate reductase enzyme yana da ƙarfi sau biyar kamar na mammalian dihydrofolate reductase.Haɗuwa tsakaninta da magungunan sulfa na iya haifar da toshewar dual zuwa folic acid biosynthesis metabolism na ƙwayoyin cuta ta yadda za a sami tasirin synergistic wanda zai haɓaka aikin ƙwayoyin cuta na ƙwayoyin sulfa, kuma yana iya juyar da tasirin antibacterial zuwa tasirin bactericidal wanda ke rage juriya na miyagun ƙwayoyi. iri.Bugu da ƙari, samfurin zai iya haɓaka tasirin ƙwayoyin cuta na wasu nau'ikan maganin rigakafi (irin su tetracycline, gentamicin).