Kayayyaki

Submillimolar taro na cytotoxic bile acid (BAs) yana haifar da mutuwar tantanin halitta ta hanyar apoptosis.A gefe guda, an nuna BAs da yawa na cytoprotective don hana apoptosis a cikin kewayon maida hankali ɗaya.Har yanzu, hanyoyin da BAs ke haifar da waɗannan saɓanin tasirin sigina ba su da tabbas.Wannan binciken an yi niyya ne don sanin ko cytotoxic da cytoprotective BAs, a cikin ɗimbin aiki na physiologically, sun sami damar daidaita abubuwan biophysical na membranes na lipid, mai yuwuwar fassara zuwa canje-canje a cikin bakin kofa na sel.An kimanta daurin BAs zuwa membranes ta hanyar bambancin sigogin haske na BAs da suka dace.Waɗannan abubuwan ɓangarorin sun rabu tare da alaƙa mai zurfi zuwa rikicewar ruwa fiye da wuraren da aka ba da umarnin ruwa mai wadatar cholesterol.Hakanan an nuna BAs marasa lakabi suna da wuri na sama akan hulɗa da membrane na lipid.Bugu da ƙari, hulɗar BAs na cytotoxic tare da membranes ya haifar da fadada membrane, kamar yadda aka tattara daga bayanan FRET.Bugu da ƙari, an nuna cewa BAs cytotoxic sun sami damar tarwatsa tsarin tsarin membrane ta hanyar cholesterol a cikin abubuwan da ke aiki da ilimin lissafi na BA, tasirin da ba a haɗa shi da cire cholesterol ba.A daya hannun, cytoprotective bile acid ba shi da wani tasiri a kan membrane Properties.An kammala cewa, da aka ba da tasirin da aka lura akan rigidity na membrane, aikin apoptotic na BAs na cytotoxic zai iya kasancewa mai yuwuwar haɗuwa da canje-canje a cikin ƙungiyar membrane na plasma (misali canjin yanki na lipid) ko tare da haɓaka alaƙar mitochondrial membrane don furotin apoptotic.