Kayayyaki

An nuna n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) da docosahexaenoic acid (DHA) don haɓaka tasirin magungunan chemotherapeutic a cikin binciken asibiti a cikin marasa lafiya na ciwon daji da kuma haifar da mutuwar ƙwayar ƙwayar ƙwayar cuta a cikin vitro.Har zuwa yanzu, EPA da DHA ba a taɓa bincikar su ba a cikin myeloma da yawa (MM).Kwayoyin myeloma na ɗan adam (L363, OPM-1, OPM-2 da U266) da kuma ƙwayoyin jini na mononuclear na yau da kullun an fallasa su zuwa EPA da DHA, kuma an auna tasirin mitochondrial da apoptosis, kunnawar caspase-3, maganganun kwayoyin halitta da kuma gubar ƙwayoyi.Bayyanawa ga EPA da DHA sun haifar da apoptosis da ƙara yawan hankali ga bortezomib a cikin ƙwayoyin MM.Mahimmanci, ba su yi tasiri ga yuwuwar sel mononuclear na ɗan adam na yau da kullun ba.Tsarin maganganu na Messenger RNA ya nuna cewa EPA da DHA masu daidaita kwayoyin halittar da ke da hannu cikin hanyoyin siginar da yawa da suka hada da sinadarin nukiliya (NF) κB, Notch, Hedgehog, danniya mai oxidative da Wnt.EPA da DHA sun hana ayyukan NFκB kuma sun haifar da apoptosis ta hanyar ruɗin mitochondrial da kunna caspase-3.Nazarinmu ya nuna cewa EPA da DHA suna haifar da tasirin cytotoxic masu zaɓi a cikin MM kuma suna haɓaka hankali ga bortezomib kuma suna kira don ƙarin bincike a cikin yuwuwar aikace-aikacen waɗannan n-3 polyunsaturated fatty acids a cikin jiyya na MM.