Kayayyaki

Platinum goma sha biyar (II) - tushen metallointercalators an haɗa su waɗanda ke amfani da maye gurbin 1,10-phenanthroline (phen) ligands, gami da 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenathroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) da dipyrido [3,2-d : 2', 3'-f] quinoxaline (dpq), da achiral ethylenediamine (en) da kuma chiral ancillary ligands 1S, 2S-diaminocyclohexane (S, S-dach) da 1R, 2R-diaminocyclohexane (R, R-dach) .Cytotoxicity su a cikin L1210 murine leukemia cell line an ƙaddara ta amfani da ƙididdigar hana haɓaka.Mafi yawan rukunin ƙarfe na cytotoxic sune waɗanda ke ɗauke da S, S-dach ancillary ligands da 5-CH3-phen intercalating ligands.Metalointercalator ɗaya [Pt (5-CH3-phen) (S, S-dach)] Cl2 (5MESS), yana nuna haɓakar cytotoxicity sau 5-10 idan aka kwatanta da wakilin asibiti na cisplatin.Daga gwaje-gwajen daurin DNA da alama babu wani babban bambanci tsakanin kowane rukunin ƙarfe, yana nuna cewa babu alaƙar DNA ko yanayin ɗaurin ɗaurin DNA da aka kafa shine kaɗai ke ƙayyade cytotoxicity na wannan dangin platinum(II) -based. metallointercalators.