Kayayyaki

Samuwar Acyl-CoA yana fara metabolism na fatty acid na salula.Acyl-CoAs ana haifar da su ta hanyar haɗar fatty acid zuwa Coenzyme A wanda babban dangi na acyl-CoA synthetases (ACS) ke shiga tsakani.Sabanin haka, acyl-CoAs na iya zama hydrolyzed ta dangin acyl-CoA thioesterases (ACOT).Anan, mun ƙididdige ƙa'idar rubutun duk ACS da ACOT enzymes a cikin kyallen takarda da kuma martani ga ɓarna na rayuwa.Mun sami tsarin daidaitawa tsakanin da tsakanin waɗannan iyalai na jinsin halittu da kuma ƙa'idodi daban-daban waɗanda ke faruwa ta hanyar dogaro da nama- da tsarin jiki.Sakamakon canje-canjen da aka lura a cikin dogon sarkar ACOT mRNA da furotin mai yawa a cikin hanta da nama mai adipose, mun ƙaddara sakamakon haɓaka aikin cytosolic dogon sarkar thioesterase akan metabolism na fatty acid a cikin waɗannan kyallen takarda ta hanyar haifar da berayen transgenic overexpressing a hyperactive mutant na Acot7 a cikin hanta ko adipose tissue.Sau biyu ayyukan cytosolic acyl-CoA thioesterase ya kasa kare mic e daga kiba da ke haifar da abinci, hanta mai kitse ko juriya na insulin, duk da haka, wuce gona da iri na Acot7 a cikin adipocytes sun sanya mice sanyi mara haƙuri.Tare, waɗannan bayanan suna ba da shawarar nau'ikan tsari daban-daban na ACS da ACOT enzymes kuma waɗannan enzymes suna aiki cikin tsari mai daidaitawa don sarrafa metabolism na fatty acid ta hanyar dogaro da nama.