Kayayyaki

Yawancin magungunan cutar kansa sun kasa kawar da ciwace-ciwacen daji, wanda ke haifar da haɓaka juriya na miyagun ƙwayoyi da sake dawowar cututtuka.Alamar Hedgehog tana taka muhimmiyar rawa yayin haɓakar amfrayo, amma kuma yana shiga cikin ci gaban kansa, ci gaba, da metastasis.Mai karɓar Hedgehog Patched (Ptc) wani nau'in siginar bushiya ce mai siginar siginar ƙwayar cuta wacce ta wuce gona da iri a yawancin ƙwayoyin cutar kansa.Anan, muna nuna hanyar haɗi tsakanin Ptc da juriya ga chemotherapy, kuma muna ba da sabon haske game da aikin Ptc.An share Ptc daga membrane na plasma akan hulɗa tare da ligand Hedgehog, ko kuma akan jiyya na sel tare da cyclopamine mai siginar Hedgehog antagonist.A cikin lokuta biyu, bayan shigar da sel tare da doxorubicin, wakili na chemotherapeutic wanda ake amfani da shi don kula da ciwon daji na yau da kullun, mun lura da hana fitar da doxorubicin daga fibroblasts mai amsawa na Hedgehog, da karuwar tarin doxorubicin a cikin nau'ikan ciwon daji guda biyu. Layukan tantanin halitta waɗanda aka san su don bayyana matakan ɓacin rai na abubuwan haɗin siginar bushiya.Yin amfani da tsarin maganganun heterologous, mun nuna ƙwaƙƙwaran cewa furcin ɗan adam Ptc ya ba da juriya ga hana haɓakar ƙwayoyin cuta da yawa daga abin da magungunan chemotherapeutic kamar doxorubicin, methotrexate, temozolomide, da 5-fluorouracil.Juriya ga doxorubicin yana da alaƙa da aikin Ptc, kamar yadda aka nuna ta yin amfani da maye gurbi daga marasa lafiya na Gorlin wanda tasirin Ptc-matsakaici akan siginar Hedgehog ya ɓace.Sakamakonmu ya nuna cewa Ptc yana da hannu a cikin zubar da ƙwayoyi da kuma juriya na ƙwayoyi masu yawa, kuma yana ba da shawarar cewa Ptc yana ba da gudummawa ga juriya na chemotherapy na kwayoyin cutar kansa.