Kayayyaki

A kan tushen ATP adenine, an shirya jerin abubuwan adenine da purine kuma an gwada su don iyawar su don hana nau'in kinases masu alaƙa da cuta.An sami ɗan ƙaramin bincike da ke bincika yuwuwar cosubstrate da aka samu kinase inhibitors don wasu kinase fiye da CDKs.Zane mai hana mu ya haɗu da tsarin purine daga asalin cosubstrate ATP da phenyl moieties don bincika yiwuwar hulɗa tare da yankuna daban-daban na rukunin yanar gizon ATP a cikin kinases masu alaƙa da cuta da yawa.An sami adadin hits don abubuwan da aka tantance, wanda ya kai mu ga ƙarshe cewa nau'ikan mahaɗan na iya tabbatar da zama kayan aikin kayan aiki mai mahimmanci don kimanta tsarin haɗin kai da zaɓin zaɓi don nau'ikan kinases iri-iri.