Kayayyaki

Shaidar kwanan nan tana goyan bayan rawar da ke fitowa na β-nicotinamide adenine dinucleotide (β-NAD (+)) azaman sabon neurotransmitter da neuromodulator a cikin tsarin jijiya na gefe -β-NAD (+) an sake shi a cikin shirye-shiryen tsoka mai laushi mai laushi da ƙwayoyin chromaffin adrenal. ta hanyar siffa ta neurotransmitter.A halin yanzu babu tabbas ko wannan yana da gaskiya ga CNS.Yin amfani da ƙaramin ɗabi'a superfusion assay da fasaha na chromatography mai ƙarfi-matsayi mai ƙarfi, muna nuna cewa babban-K (+) haɓakawar bera na gaban kwakwalwar synaptosomes yana haifar da ambaliya na β-NAD (+), adenosine 5'-triphosphate, da su metabolites adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate, adenosine, ADP-ribose (ADPR) da cyclic ADPR.Babban-K (+) - zubar da ruwa na β-NAD (+) yana raguwa ta hanyar raguwa na SNAP-25 tare da botulinum neurotoxin A, ta hanyar hana nau'in nau'in wutar lantarki na Ca (2+) tare da ω-conotoxin GVIA. , kuma ta hanyar hana proton gradient na synaptic vesicles tare da bafilo mycin A1, yana nuna cewa β-NAD (+) ana iya fitowa ta hanyar exocytosis vesicle.Binciken Yammacin Turai ya nuna cewa CD38, furotin mai aiki da yawa wanda ke daidaita β-NAD (+), yana samuwa akan membranes synaptosomal da kuma a cikin cytosol.Ingantattun synaptosomes suna lalata β-NAD(+) .1, N (6) -etheno-NAD, analog mai kyalli na β-NAD (+), ana ɗaukar shi ta hanyar synaptosomes kuma wannan haɓakar an rage ta ta ingantaccen β-NAD (+), amma ba ta hanyar connexin 43 inhibitor Gap 27 ba. A cikin ƙananan ƙwayoyin ƙwayoyin cuta na aikace-aikacen gida na β-NAD (+) suna haifar da saurin Ca (2+) masu wucewa, mai yiwuwa saboda kwararar Ca (2+).Sabili da haka, synaptosomes na kwakwalwa na bera na iya sakin jiki, ragewa da kuma ɗaukar β-NAD (+), da β-NAD (+) na iya ƙarfafa neurons na postsynaptic, duk ma'auni da ake buƙata don wani abu da za a yi la'akari da dan takarar neurotransmitter a cikin kwakwalwa.