Kayayyaki

Mai karɓar H4 na histamine (HRH4), wanda aka gano shekaru 13 da suka gabata, ana ɗaukar shi azaman maƙasudin miyagun ƙwayoyi don rashin lafiyan, kumburi, cututtukan autoimmune da ciwon daji, kamar yadda ake nunawa ta ci gaba da haɓaka adadin littattafan kimiyya da aikace-aikacen haƙƙin mallaka.Ko da yake an tabbatar da kasancewar HRH4 a cikin gwajin gwajin, ba a tabbatar da takamaiman wurinsa ko matsayinsa ba.A nan, mun nemi gano yuwuwar shigar HRH4 a cikin ƙa'idar aikin tantanin halitta Leydig.Mun fara kimanta bayaninsa a cikin ƙwayoyin tumor MA-10 Leydig sannan mu tantance tasirin agonists guda biyu na HRH4 akan steroidogenesis da haɓakawa.Mun gano cewa HRH4 yana aiki a cikin sel MA-10, kuma cewa kunnawa yana haifar da hana LH / mutum chorionic gonadotropin-induced cAMP samar da furotin na STAR.Bugu da ƙari kuma, mun lura da raguwar yaduwar kwayar halitta bayan 24-h HRH4 agonist magani.Daga nan mun gano shafukan HRH4 a cikin al'ada na bera tes tis, kuma mun gano HRH4 immunostaining a cikin kwayoyin Leydig na berayen da ke da shekaru 7-240, yayin da 21-day-day berayen kuma sun gabatar da maganganun HRH4 a cikin maza.A ƙarshe, mun ƙididdige tasirin kunnawa na HRH4 akan yaduwa na al'ada na al'ada da al'adun bera Leydig, kuma duka biyun sun tabbatar da cewa sun kasance masu saurin kamuwa da tasirin HRH4 agonists.Ganin mahimmancin histamine (2- (1H-imidazol-4-yl) ethanamine) a cikin ɗan adam (pato) physiology, ana ci gaba da ƙoƙarin ƙoƙarin haɓaka abubuwan da ke fitowa na HRH4 da ligands.Wannan binciken yana bayyana sabbin rukunin yanar gizo na maganganun HRH4, kuma yakamata a yi la'akari da su a cikin ƙirar zaɓaɓɓun agonists na HRH4 don dalilai na warkewa.