Kayayyaki

Ɗaya daga cikin mahimman hanyoyin warkewa don kula da nau'in ciwon sukari na 2 shine amfani da wakilai waɗanda zasu iya rage hyperglycemia na postprandial ta hanyar hana enzymes narkewar carbohydrate.Binciken da aka yi a yanzu ya binciki tasirin tsantsa mai shiryarwa na bioassay da ɓangarorin busassun 'ya'yan itace pericarp na Phaleria macrocarpa, tsire-tsire na gargajiya na rigakafin ciwon sukari, akan α-glucosidase da α-amylase, a ƙoƙarin fahimtar tsarin rigakafin ciwon sukari, kamar yadda kazalika da yiwuwar attenuation mataki a kan postprandial glucose karuwa.Methanol tsantsa (ME), samu ta m sauran ƙarfi hakar, da mafi inganci ruwa-ruwa n-butanol juzu'i (NBF) da flash shafi chromatographic sub-juzu'i (SFI), aka kimanta. don in vitro α-glucosidase (yiast) da α-amylase (porcine) hana ayyukan.Bugu da ƙari kuma, an gudanar da gwaje-gwajen tabbatarwa a cikin vivo a cikin berayen masu ciwon sukari na streptozotocin (SDRs) ta amfani da glucose na baka, sucrose da gwajin haƙuri na sitaci. 75%) da α-amylase (87%) a cikin vitro (IC50 = 2.40 ± 0.23 μg / ml da 58.50 ± 0.13 μg / ml, bi da bi) a cikin yanayin dogara ga kashi;wani sakamako da aka samu game da 20% mafi girma fiye da acarbose (55%), ma'auni na α-glucosidase inhibitor (IC50 = 3.45 ± 0.19 μg / ml).ME da SFI kuma sun hana α-glucosidase (IC50 = 7.50 ± 0.15 μg/ml da 11.45 ± 0.28 μg/ml) da α-amylase (IC50 = 43.90 ± 0.19 μg/ml da 69.82 ± g) amma zuwa 69.80 μg. kadan.A cikin nazarin vivo tare da berayen masu ciwon sukari, NBF da SFI da kyau sun rage girman glucose na jini (PBG) da 15.08% da 6.46%, kuma yankin da ke ƙarƙashin tsarin haƙuri (AUC) da 14.23% da 12.46%, bi da bi, bayan ƙalubalen sucrose na baki. (P <0.05);don haka tabbatar da abin da aka lura a cikin vitro.Wadannan raguwar tasirin akan PBG da AUC kuma an nuna su a cikin gwajin haƙuri na glucose da sitaci, amma zuwa ƙaramin digiri.Waɗannan binciken sun nuna cewa P. macrocarpa na iya rage hyperglycaemia a cikin yanayin in vitro da a cikin yanayin vivo ta hanyar hana carbohydrate hydrolysing enzymes da ƙarfi, yin shi. shuka mai yuwuwa don samo mahaɗan halitta don sarrafa nau'in ciwon sukari na 2.