Kayayyaki

Mai hana fibrinolysis na thrombin-activatable (TAFIa) shine carboxypeptidase mai dauke da zinc kuma yana hana fibrinolysis mahimmanci.Don haka ana sa ran masu hana TAFIa suyi aiki azaman wakilai na profibrinolytic.Kwanan nan mun ba da rahoton ƙira da haɗin gwiwar masu hana TAFIa mai ɗauke da selenium da ayyukan hana su.Anan mun ba da rahoton sifofin crystal na maƙarƙashiyar selenium-, sulfur-, da phosphinic acid mai ɗauke da inhibitors waɗanda ke daure da ƙwayar pancreatic carboxypeptidase B (ppCPB).ppCPB homologue ne na TAFIa kuma an maye gurbin TAFIa don nazarin crystallographic.Siffofin kristal na ppCPB da aka haɗa su tare da mahallin selenium 1a, sulfur analogue 2, da phosphinic acid wanda aka samu EF6265 an ƙaddara a 1.70, 2.15, da 1.90 Å ƙuduri, bi da bi.Kowane mai hanawa yana ɗaure zuwa wurin aiki na ppCPB daidai da wanda aka lura ga masu hanawa da aka ruwaito a baya.Don haka, a cikin hadaddun, selenium, sulfur, da phosphinic acid oxygen suna daidaitawa zuwa zinc a cikin ppCPB.Wannan shine farkon lura da rahoto na daidaitawar selenium zuwa zinc a cikin CPB.