Kayayyaki

Wani wallafe-wallafen da ke fitowa ya nuna cewa bisphenol A (BPA), wani nau'i mai yaduwa na endocrin da ke rushe sinadarai, lokacin da fallasa ya faru a farkon rayuwa, na iya ƙara haɗarin ciwo na rayuwa.A cikin wannan binciken, mun bincika hasashen cewa bayyanar mahaifa ga BPA ya haifar da zuriya ga cututtukan hanta mai kitse: bayyanar hanta na ciwo na rayuwa, da kuma tsarin da zai yiwu.An yi amfani da berayen Wistar masu ciki tare da BPA (40μg/kg/day) ko abin hawa a lokacin gestation da lactation.Nazarin ilimin hanta, nazarin halittu na biochemical, transcriptome, da aikin mitochondrial an bincika su a cikin zuriyar maza a cikin makonni 3, 15 da 26 bayan haihuwa.A cikin makonni 3 da haihuwa, ba a lura da yanayin hanta da aikin hanta na al'ada ba a cikin zuriyar da aka fallasa ta BPA, amma raguwa a cikin hadaddun numfashi na mitochondrial (MRC) (I da III) da kuma canje-canje masu mahimmanci a cikin maganganun kwayoyin da ke cikin mitochondrial fatty acid metabolism. lura idan aka kwatanta da sarrafawa.A cikin makonni 15, micro-vesicular steatosis a cikin hanta, kwayoyin halitta masu tasowa da ke cikin hanyoyin lipogenesis, haɓakar ROS da sakin Cytc a cikin zuriyar da aka fallasa ta BPA.Sa'an nan kuma, an lura da tarin kitse mai yawa a cikin hanta da hawan jini ALT a cikin zuriyar da aka fallasa BPA a makonni 26.A cikin lura na tsayin lokaci, aikin mitochondrial na hanta ciki har da ayyukan MRC, samar da ATP, tsarar ROS da yuwuwar mitochondrial membrane sun ci gaba da tsananta a cikin zuriyar da aka fallasa ta BPA.Bayyanar BPA na Perinatal yana ba da gudummawa ga haɓakar steatosis na hanta a cikin zuriyar berayen, wanda za'a iya yin sulhu ta hanyar gurɓataccen aikin mitochondrial na hanta da haɓakar metabolism na hanta.