D-Valine Cas: 640-68-6 C5H11NO2
| Lambar Catalog | Saukewa: XD90291 |
| Sunan samfur | D-Valine |
| CAS | 640-68-6 |
| Tsarin kwayoyin halitta | Saukewa: C5H11NO2 |
| Nauyin Kwayoyin Halitta | 117.14634 |
| Bayanin Ajiya | Daki Temp |
| Harmonized Tariff Code | 29224995 |
Ƙayyadaddun samfur
| Assay | 99% |
| Bayyanar | Farin foda |
| Yawan yawa | 1.2000 (kimanta) |
| Wurin narkewa | > 295 ° C (sl.) (lit.) |
| Wurin tafasa | 213.6 ° C a 760 mmHg |
| Ma'anar walƙiya | 83 ℃ |
| Indexididdigar refractive | -27 ° (C=8, 6mol/L HCl) |
| Solubility | 56 g/L (20°C) |
| Ruwa mai narkewa | 56 g/L (20ºC) |
| PSA | 63.32000 |
| LogP | 0.75460 |
| Takamaiman juyawa | -27.5º (c=5, 5N HCl) |
| Ayyukan gani | [α] 23/D -32.0 zuwa -24.0°, c = 8 a 6 M HCl |
Mata masu fama da ciwon antiphospholipid (APS) suna cikin haɗarin sake dawowa ciki (RPL) da preeclampsia.Antiphospholipid antibodies (aPL) kai tsaye canza aikin trophoblast.Jiyya tare da ƙananan nauyin heparin (LMWH) yana rage haɗarin RPL amma ba preeclampsia ba.Bugu da ƙari, LMWH yana ƙarfafa trophoblast sFlt-1 saki, wani abu na anti-angiogenic da ke hade da preeclampsia.Tun da raunin bitamin D yana hade da APS da preeclampsia, wannan binciken ya nemi sanin tasirin bitamin D akan aikin trophoblast a cikin saitin aPL da LMWH.A ɗan adam na farko trimester trophoblast cell line (HTR8) da kuma al'adun trophoblast na farko an bi da su tare da ko ba tare da aPL ba a gaban da rashin bitamin D, LMWH ko duka biyu.Ƙwararrun ƙwayar cuta na cytokines mai kumburi da abubuwan angiogenic an auna su ta hanyar ELISA.Vitamin D kadai ko a hade tare da LMWH ya ƙaddamar da aPL-induced trophoblast inflammatory amsa a cikin kwayoyin HTR8 da al'adu na farko.Duk da yake bitamin D ba shi da wani tasiri a kan gyaran gyare-gyare na aPL na abubuwan angiogenic a cikin trophoblast na farko, ya hana LMWH-induced sFlt-1 release. LMWH a hade tare da bitamin D na iya zama mafi amfani fiye da maganin wakili guda ɗaya ta hanyar hana aPL -induced trophoblast kumburi da kuma mayar da LMWH-induced sFlt-1 asiri.
