Dirhodium tetraacetate CAS: 15956-28-2 99% Green-black lu'ulu'u
| Lambar Catalog | XD90641 |
| Sunan samfur | Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| Tsarin kwayoyin halitta | Saukewa: C8H12O8Rh2 |
| Nauyin Kwayoyin Halitta | 441.987 |
| Bayanin Ajiya | yanayi |
| Harmonized Tariff Code | Farashin 28439000 |
Ƙayyadaddun samfur
| Bayyanar | Green-black lu'ulu'u |
| Assay | 99% |
Haɗin haɗin kai na N7/O6 equatorial na haɗin gwiwar antitumor mai aiki Rh (2) (OAc) (4) (H (2) O) (2) (OAc (-) = CH (3) CO (2) (-)) tare da guntuwar DNA d (GpG) an ƙaddara su ba tare da shakka ba ta hanyar NMR spectroscopy.Ƙididdigar X-ray crystallographic na baya na kai-da-kai (HH) da kai-zuwa-wutsiya (HT) adducts na dirhodium tetraacetate tare da 9-ethylguanine (9-EtGH) ya bayyana abubuwan da ba a taɓa gani ba N7 / O6 guanine nucleobases wanda ke kan Rh - Rh bond.Rashin N7 protonation a low pH da kuma sanannen karuwa a cikin acidity na N1-H (pK (a) kusan 5.7 idan aka kwatanta da 8.5 don N7 kawai daure platinum adducts), shawarar pH dogara titrations na purine H8 (1). H NMR resonances na Rh (2) (OAc) (2) (9-EtG) (2) da Rh (2) (OAc) (2-) [d (GpG)], sun yi daidai da bidentate N7/O6 dauri guanine nucleobases.Ƙimar pK (a) da aka kiyasta don N1-H (de) protonation, daga nazarin dogara da pH na C6 da C2 (13) C NMR resonances na Rh (2) (OAc) (2) (9-EtG) 2) isomers, concur tare da t tiyo da aka samo daga H8 (1) H NMR resonance titration.Kwatanta (13) C NMR resonances na C6 da C2 don dirhodium adducts Rh (2) (OAc) (2) (9-EtG) (2) da Rh (2) (OAc) (2) [d (GpG) )] tare da ma'auni na ma'auni na haɗin da ba a haɗa su ba [a pH 7.0 don 9-EtGH da pH 8.0 don d (GpG)], yana nuna sauye-sauye masu mahimmanci na Deltadelta kamar 11.0 da 6.0 ppm don C6 da C2, bi da bi;sauye-sauye na ƙarshe suna nuna tasirin O6 daure zuwa cibiyoyin dirhodium da haɓakawa mai zuwa a cikin acidity na N1-H.Ƙunƙarar H8/H8 ROE-kololuwa a cikin 2D ROESY NMR bakan Rh(2)(OAc)(2)[d(GpG)] yana nuna tsarin kai-da-kai na sansanonin guanine.Rh (2) (OAc) (2) [d (GpG)] adduct yana nuna manyan masu haɗa hannun dama guda biyu, HH1 R da HH2 R, tare da HH1 R ya ninka sau uku fiye da HH2 R da ba a saba ba. Cikakkar halayyar duka biyun. adducts ya bayyana repuckering na 5'-G sugar zobe zuwa C3'-endo (N-type), riƙewar C2'-endo (S-type) conformation ga 3'-G sugar ring gs, da anti fuskantarwa game da glycosyl bond.Siffofin tsarin da aka samo don Rh (2) (OAc) (2)) [d (GpG)] ta hanyar NMR spectroscopy sun yi kama da na cis-[Pt (NH (3)) (2)) [d() GpG)]] da kuma ingantaccen nazarin ƙirar ƙwayoyin ƙwayoyin cuta.
