Fluorescein 5-Isothiocyanate (isomer I) CAS: 3326-32-7
| Lambar Catalog | XD90514 |
| Sunan samfur | Fluorescein 5-Isothiocyanate (isomer I) |
| CAS | 3326-32-7 |
| Tsarin kwayoyin halitta | Saukewa: C21H11NO5S |
| Nauyin Kwayoyin Halitta | 389.38 |
| Bayanin Ajiya | 2 zuwa 8 ° C |
| Harmonized Tariff Code | Farashin 32129000 |
Ƙayyadaddun samfur
| Bayyanar | Foda mai launin rawaya |
| Assay | 99% |
An nuna bugun jini na ischemic yana haifar da hypermetabolism na glucose a cikin penumbra ischemic.Bayanan gwaji da na asibiti sun nuna cewa hyperglycemia na tsarin da ke da alaƙa da infarct shine yuwuwar manufa ta warkewa a cikin mummunan bugun jini.Duk da haka, nazarin asibiti da ke nufin sarrafa glucose a cikin mummunan bugun jini bai inganta sakamakon aiki ba ko rage mace-mace.Don haka, ƙarin binciken akan metabolism na glucose a cikin kwakwalwar ischemic yana da garantin. Mun yi amfani da samfurin bera na bugun jini wanda ke kiyaye kwararar ruwa.An bincika dabbobin ta [2- (18) F] -2-fluoro-2-deoxy-d-glucose positron emission tomography ko maganadisu rawa a lokacin 90-minti occlusion na tsakiyar cerebral artery da kuma a lokacin 60 minutes bayan reperfusion.Sakamakon yana da alaƙa da hoton maganadisu na magnetic resonance na jini na jini, yaduwar ruwa, samuwar lactate, da bayanan tarihi game da mutuwar kwayar halitta da rushewar shingen jini-kwakwalwa.Mun gano karuwa [2- (18) F] -2-fluoro-2 -deoxy-d-glucose da ake samu a cikin ischemic re gions wanda ke kaiwa ga ciwon infarction da kuma a cikin yankin peri-infarct.Hoto na Magnetic Resonance Hoton ya nuna rashin lahani na jini zuwa matakan ischemic a cikin infarct da kuma raguwar jini na kwakwalwa a cikin yankin peri-infarct.Magnetic resonance spectroscopy ya bayyana lactate a cikin yankin ischemic da kuma rashin lactate a cikin yankin peri-infarct.Immunohistochemical bincike ya bayyana apoptosis da jini-kwakwalwa rushewar shinge a cikin infarct.Ƙara yawan amfani da [2- (18) F] -2-fluoro-2-deoxy-d-glucose a cikin ischemia cerebral mai yiwuwa yana nuna hypermetabolism na taron glucose ya karu da makamashi. bukatun ischemic da hypoperfused kwakwalwar nama, kuma yana faruwa a ƙarƙashin yanayin anaerobic da aerobic da aka auna ta hanyar samar da lactate na gida.Hyperglycemia na tsarin da ke da alaƙa da infarct zai iya taimakawa don sauƙaƙe wadatar glucose zuwa kwakwalwar ischemic.Sarrafa glycemic ta hanyar jiyya na insulin na iya yin mummunan tasiri ga wannan tsarin.
