Kayayyaki

Kiba, nau'in ciwon sukari na 2 da hyperlipidemia akai-akai suna kasancewa tare kuma suna da alaƙa da haɓakar cututtuka da mace-mace.Amfani da ingantaccen carbohydrate da musamman fructose ya karu sosai a cikin 'yan shekarun nan kuma ya yi daidai da karuwar yawan kiba da ciwon sukari.Nazarin ɗan adam da na dabba sun nuna cewa yawan cin fructose na abinci yana da alaƙa da haɓakar dyslipidemia, juriya na insulin, da hauhawar jini.Metabolism na fructose yana faruwa da farko a cikin hanta kuma babban fructose flux yana haifar da haɓaka haɓakar hanta triglyceride (hepatic steatosis).Wannan yana haifar da gazawar glucose da metabolism na lipid da ƙara yawan maganganun cytokine na proinflammatory.Anan mun nuna cewa fructose yana canza yanayin motsa jiki na glucose na acetyl CoA carboxylase (ACC) da aka kunna, pSer hormone mai hankali lipase (pSerHSL) da adipose triglyceride lipase (ATGL) a cikin hepatic HepG2 ko al'adun hanta na farko a cikin vitro.Wannan yana da alaƙa da haɓakar de novo triglyceride kira a cikin vitro da hanta steatosis a cikin vivo a cikin fructose-fid da glucose-feed da daidaitaccen abinci mai ciyar da beraye.Waɗannan karatun suna ba da sabon haske game da hanyoyin da ke cikin fructose-mediated hepatic hypertriglyceridemia da gano ɗaukar fructose a matsayin sabon maƙasudin warkewa don cututtukan da ke da alaƙa da lipid.