Kayayyaki

Fina-finan mucoadhesive da ke ɗauke da nanoparticles masu ɗauke da curcumin an haɓaka, da nufin tsawaita lokacin zama na nau'in sashi a cikin rami na baka da kuma ƙara yawan shan miyagun ƙwayoyi ta cikin mucosa na buccal.An shirya fina-finai ta hanyar simintin gyare-gyare bayan haɗa nanoparticles polycaprolactone mai lulluɓe da curcumin a cikin mafita na chitosan filastik.An yi amfani da nau'ikan ƙwanƙwasa daban-daban na mucoadhesive polysaccharide chitosan da yawa na glycerol na filastik don inganta yanayin shirye-shiryen.Fina-finan da aka samu ta hanyar amfani da matsakaici da babban ƙwanƙwasa chitosan an gano suna da kamanni da sassauƙa.An rarraba nau'ikan nanoparticles da aka ɗora da curcumin daidai gwargwado a kan fuskar fim ɗin, kamar yadda aka tabbatar ta hanyar microscopy mai ƙarfi ta atomic da babban ƙudurin filin-fige-fige gun sikanin microscopy na lantarki (FEG-SEM).Binciken sassan giciye na fim ta amfani da FEG-SEM yana nuna kasancewar nanoparticles a cikin fina-finai.Bugu da ƙari, fina-finai sun tabbatar da cewa suna da kyakkyawan adadin hydration a cikin maganin saliva da aka kwatanta, suna nuna matsakaicin kumburi na kusan 80% da kuma in vitro na tsawon lokaci mai sarrafawa na curcumin.Waɗannan sakamakon sun nuna cewa fina-finan mucoadhesive da ke ɗauke da nanoparticles suna ba da kyakkyawar hanya don isar da buccal na curcumin, wanda zai iya zama da amfani musamman a cikin maganin cututtukan periodontal waɗanda ke buƙatar isar da magani mai dorewa.© 2014 Wiley Periodicals, Inc.