Kayayyaki

Melatonin yana da hannu a yawancin ayyuka na ilimin lissafin jiki, kuma yana da tasiri daban-daban akan apoptosis a cikin al'ada da kwayoyin cutar kansa.Duk da haka, ba a fahimci tsarin ayyukan antitumor da kyau ba.A cikin wannan binciken, mun nuna cewa melatonin yana haɓaka apoptosis mai haifar da tunicamycin a cikin ƙwayar nono na mutum MDA-MB-231 Kwayoyin.Melatonin yana sarrafa furotin Bim pro-apoptotic magana a matakan rubutu a gaban tunicamycin.Melatonin yana hana tunicamycin-induced COX-2 magana a cikin sel MDA-MB-231.Bugu da ƙari kuma, hana ayyukan COX-2 ta amfani da COX-2 inhibitor, NS398, yana ƙaruwa apoptosis mai haifar da tunicamycin.Abin sha'awa, waɗannan tasirin ba su da alaƙa da hanyoyin siginar mai karɓar melatonin.Pertussis toxin (mai hana furotin na gabaɗaya Gi) ko luzindole (mai adawa da mai karɓar melatonin wanda ba takamaiman ba) bai canza tasirin melatonin ba.Bugu da ƙari, melatonin ya katange tunicamycin-induced NF-κB aikin rubutun, p65 fassarar nukiliya, da p38 MAPK aiki ivation.Melatonin-matsakaici p38 hanawa MAPK ya ba da gudummawa ga raguwar kwanciyar hankali na COX-2 mRNA.A hade tare, sakamakonmu yana nuna cewa melatonin yana haɓaka aikin antitumor ta hanyar haɓaka-ka'idar magana ta Bim da ka'ida ta hanyar COX-2 a cikin ƙwayoyin MDA-MB-231 da aka yi wa tunicamycin magani.