Kayayyaki

An nuna furotin na cerebral dopamine neurotrophic factor (CDNF) don kare hanyar nigrostriatal dopaminergic lokacin da aka ba da shi azaman infusions intrastriatal a cikin bera da nau'ikan linzamin kwamfuta na cutar Parkinson (PD).A cikin wannan binciken, mun kimanta tasirin neuroprotective na CDNF wanda aka kawo tare da recombinant adeno-associated viral (AAV) serotype 2 vector a cikin rat 6-hydroxydopamine (6-OHDA) samfurin PD.AAV2 vectors ɗin da ke ɓoye CDNF, glial cell line-derived neurotrophic factor (GDNF), ko furotin mai kyalli ko kore an allura a cikin bera striatum.Binciken furuci na furotin ya nuna cewa vector ɗin mu na AAV2 ya isar da ƙayyadaddun kwayoyin halittar neurotrophic a cikin kwakwalwa kuma ya haifar da bayanin sunadaran na dindindin.Makonni biyu bayan allurar vector na AAV2, 6-OHDA an allurar a cikin bera striatum, yana haifar da haɓakar ci gaba na tsarin dopaminergic na nigrostriatal.Jiyya tare da AAV2-CDNF ya haifar da raguwa mai mahimmanci a cikin jujjuyawar ipsilateral na amphetamine yayin da yake ba da kariya kawai na tyrosine hydroxylase (TH) -immunoreactive Kwayoyin a cikin bera substantia nigra pars compacta da TH-reactive fibers a cikin striatum.Sakamakon wannan binciken ya ba da ƙarin shaida cewa CDNF za a iya la'akari da yiwuwar maganin cutar Parkinson.