Guanidine Hydrochloride Cas: 50-01-1 99% Farin foda
| Lambar Catalog | XD90198 |
| Sunan samfur | Guanidine Hydrochloride |
| CAS | 50-01-1 |
| Tsarin kwayoyin halitta | Saukewa: CH6N3Cl |
| Nauyin Kwayoyin Halitta | 95.5388 |
| Bayanin Ajiya | yanayi |
| Harmonized Tariff Code | 29252900 |
Ƙayyadaddun samfur
| Matsayin narkewa | 185.3 - 187.5 Deg C |
| Ruwa | <0.3% |
| Solubility | Bayyana bayani mara launi a 6M a cikin Ruwa |
| Assay | >99% |
| UV Absorbance | 0.10 a 260nm |
| Bayyanar | Farin foda |
| IR bakan | Ya dace |
Ɗaya daga cikin abubuwan da ke hana aikace-aikacen asibiti na maganin farfadowa zuwa cututtuka na guringuntsi mai lalacewa shine tushen sel mai dacewa.Chandrocytes, nau'in sel kawai na carlage, girma a cikin yanayin al'adun gargajiya ya faɗi phenotype tare da ikon samar da ƙwayar ƙwayar cuta ta Hyaline.A cikin wannan binciken mun ƙayyade cewa tsarin al'ada na nau'i-nau'i da haɓaka-free-free uku-girma (3D) tsarin al'ada ya mayar da ikon chondrocytes da ke wucewa don samar da nama na guringuntsi a cikin vitro, wani tsari wanda ya ƙunshi sox9.Bovine articular chondrocytes sun wuce sau biyu zuwa sau biyu zuwa uku. ba da izinin faɗaɗa lambar tantanin halitta (P2) da kuma al'ada da yawa akan 3D collagen-type-II-rufin membranes a cikin babban abun ciki na glucose a cikin kafofin watsa labarai wanda aka ƙara da insulin da dexamethasone (SF3D).An siffanta sel bayan haɓakar monolayer da bin al'adun 3D ta hanyar cytometry kwarara, bayanin kwayoyin halitta, da tarihi.Canje-canje na farko a cikin hanyoyin siginar sigina a lokacin rediferentiat ion an kwatanta su.Kwayoyin P2 sun nuna alamar antigen-kamar progenitor na 99% CD44 (+) da 40% CD105 (+) da kuma bayanan bayanan kwayoyin halitta wanda ke nuna alamun interzone.P2 a cikin SF3D ya bayyana kwayoyin halittar chondrogenic da tara matrix na waje.Rage sarrafa mai karɓar insulin (IR) tare da HNMPA- (AM3) ko hanyar PI-3/AKT kinase (wanda aka kunna ta hanyar insulin) tare da Wortmannin ya hana haɗin collagen.HNMPA- (AM3) ya rage maganganun Col2, Col11, da IR genes da Sox6 da -9.Co-immunoprecipitation da chromatin immunoprecipitation bincike na HNMPA- (AM3) - Kwayoyin da aka bi da su sun nuna nauyin haɗin gwiwar Sox6 da Med12 tare da Sox9 amma an rage nauyin Sox9-Col2a1. Mun bayyana hanyar al'ada na al'ada wanda ke ba da damar karuwa a cikin adadin chondrocytes da ingantawa. Samuwar kyallen guringuntsi-kamar hyaline a wani bangare ta hanyar daurin insulin-mai daidaitawa Sox9-Col2a1.Dacewar nama da aka samar ta wannan hanyar don amfani da shi wajen gyaran haɗin gwiwa yana buƙatar bincika a vivo.
