Kayayyaki

Idiopathic pulmonary fibrosis ana tsammanin ya ƙunshi raunin huhu wanda ya haifar da nau'in oxygen mai amsawa (ROS), wanda kuma ya biyo bayan fibrosis mara kyau.Mahimmin haɓaka mai canzawa (TGF) -β1 haɓakawa a cikin lambar myofibroblast yana taka muhimmiyar rawa a cikin wannan fibrosis mara kyau.Kwanan nan mun gano cewa mepenzolate bromide (mepenzolate), wanda aka yi amfani da shi a asibiti don magance cututtuka na gastrointestinal, yana da kayan rage ROS.A cikin binciken yanzu, mun bincika tasirin mepenzolate akan fibrosis na huhu da ke haifar da bleomycin da rashin aikin huhu a cikin mice.An kimanta tsananin fibrosis na huhu ta hanyar kimantawa na histopathologic da ƙaddara matakan hydroxyproline.An tantance injiniyoyin huhu (elastance) da aikin numfashi [tilastawa mai mahimmancin iya aiki (FVC)] ta amfani da na'urar iska mai sarrafa kwamfuta.Hakanan an kimanta aikin numfashi ta hanyar sa ido kan jikewar iskar oxygen ta percutaneous (SpO2).Gudanar da intracheal na mepenzolate kafin maganin bleomycin ya rage girman fibrosis na huhu da canje-canje a cikin injin huhu kuma ya haifar da farfadowa mai mahimmanci na FVC da SpO2 idan aka kwatanta da sarrafawa.Bugu da ƙari kuma, mepenzolate ya haifar da sakamako na warkewa ko da lokacin da aka gudanar da shi bayan ci gaban fibrosis.Gudanar da mepenzolate kuma ya hana bleomycin haifar da mutuwar kwayar cutar huhu da amsa mai kumburi da ƙara lambar myofibroblast.Mepenzolate kuma ya rage ayyukan NADPH oxidase da matakin TGF-β1 mai aiki ko haɓaka ayyukan glutathione S-transferase (GST) a gaban jiyya na bleomycin.Wadannan sakamakon sun nuna cewa kulawar intracheal na mepenzolate ya rage ƙwayar fibrosis na huhu na bleomycin da rashin aikin huhu a cikin mice.Wadannan tasirin na iya zama saboda tasirin hanawa na wannan magani akan ayyukan NADPH oxidase da ayyukan TGF-β1 da tasirin sa akan GST.