Kayayyaki

Peptides dauke da maimaita 8 na aspartate-serine-serine (8DSS) an nuna don inganta ƙaddamar da ƙwayar calcium phosphate daga bayani a cikin enamel ɗan adam.Anan mun gwada ƙarfin 8DSS don haɓaka haɓakar haɓakar enamel da aka lalata a cikin ƙirar in vitro na farkon enamel caries.An ƙirƙiri raunuka na farko na caries a cikin tubalan enamel na bovine, waɗanda aka sanya su zuwa 12 d na hawan keke na pH a gaban 25 µM 8DSS, 1 g/L NaF (madaidaicin iko) ko buffer kaɗai (ikon mara kyau).An tabbatar da ɗaukar 8DSS ta hanyar X-ray photoelectron spectroscopy.Ma'adinan ma'adinai, zurfin rauni, da abun ciki na ma'adinai a saman Layer da kuma a zurfin daban-daban na jikin jikin an yi nazari kafin da kuma bayan hawan keke na pH ta hanyar microscopy haske mai haske da ƙananan microradiography.Asarar ma'adinai bayan hawan keken pH ya ragu sosai a cikin samfuran 8DSS fiye da samfuran buffer-kawai, kuma raunuka a cikin samfuran 8DSS ba su da zurfi sosai.Samfuran da aka bi da su tare da 8DSS sun nuna mahimmancin abun ciki na ma'adinai fiye da samfuran buffer-kawai a cikin yankin da ke fitowa daga saman saman (30 µm) zuwa matsakaicin zurfin rauni (110 μm).Ba a sami bambance-bambance masu mahimmanci tsakanin samfuran da aka yi da 8DSS da waɗanda aka yi da NaF ba.Waɗannan binciken sun nuna cewa 8DSS na da yuwuwar haɓaka haɓakar haɓakar enamel da aka lalatar da ita.