Kayayyaki

Adenosine na nucleoside yana aiki akan tsarin juyayi da tsarin zuciya ta hanyar mai karɓar A2A (A2AR).Dangane da matakin iskar oxygen a cikin kyallen takarda, ana tsara maida hankali na plasma adenosine musamman ta hanyar kira ta CD73 kuma ta hanyar lalata ta adenosine deaminase (ADA).Endopeptidase CD26 na cell-surface yana sarrafa maida hankali na peptides na vasoactive da antioxidant kuma don haka yana daidaita isar da iskar oxygen zuwa kyallen takarda da amsawar damuwa.Ko da yake overexpression na adenosine, CD73, ADA, A2AR, da CD26 don mayar da martani ga hypoxia an rubuta su da kyau, tasirin hyperoxic da hyperbaric akan waɗannan abubuwa sun cancanci ƙarin la'akari.Berayen da layin salula na murine Chem-3 wanda ke bayyana A2AR an fallasa su zuwa mashaya 0.21 O2, mashaya 0.79 N2 (yanayin ƙasa; normoxia);1 mashaya O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bar O2, 1.79 bar N2 (hyperbaria).Adenosine plasma maida hankali, CD73, ADA, A2AR magana, da kuma CD26 aiki aka magana a cikin vivo, da kuma cAMP samar da aka magance a cikin cellulo.Domin a cikin yanayin vivo, 1) hyperoxia ya rage matakin plasma adenosine da aikin T cell surface CD26, yayin da ya kara yawan maganganun CD73 da matakin ADA;2) hyperbaric hyperoxia yana kula da haɓaka yanayin;da 3) hyperbaria kadai ba ta da tasiri mai mahimmanci akan waɗannan sigogi.A cikin kwakwalwa da kuma a cikin cellulo, 1) hyperoxia ya rage maganganun A2AR;2) hyperbaric hyperoxia ya haɓaka yanayin;da 3) hyperbaria kadai ya nuna tasiri mafi karfi.Mun sami irin wannan tsari game da haɗin A2AR mRNA a cikin kwakwalwa da kuma samar da cAMP a cikin ƙwayoyin Chem-3.Don haka babban matakin iskar oxygen yana kula da rage daidaita hanyar adenosinergic da ayyukan CD26.Hyperbaria kadai ya shafi maganganun A2AR kawai da kuma samar da cAMP.Mun tattauna yadda irin waɗannan hanyoyin da ke haifar da hyperoxygenation na iya iyakance, ta hanyar vasoconstriction, isar da iskar oxygen zuwa kyallen takarda da samar da nau'in oxygen mai amsawa.